methyl 3-((2,6-dimethoxy-5-nitropyrimidin-4-yl)(phenyl)amino)propanoate

Base Information

Chemical Name:methyl 3-((2,6-dimethoxy-5-nitropyrimidin-4-yl)(phenyl)amino)propanoate
CAS No.:1398113-56-8
Molecular Formula:C₁₆H₁₈N₄O₆
Molecular Weight:362.342
Hs Code.:

Synonyms:methyl 3-((2,6-dimethoxy-5-nitropyrimidin-4-yl)(phenyl)amino)propanoate

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Chemical Property of methyl 3-((2,6-dimethoxy-5-nitropyrimidin-4-yl)(phenyl)amino)propanoate

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Technology Process of methyl 3-((2,6-dimethoxy-5-nitropyrimidin-4-yl)(phenyl)amino)propanoate

There total 1 articles about methyl 3-((2,6-dimethoxy-5-nitropyrimidin-4-yl)(phenyl)amino)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 21911-84-2
methyl 3-(phenylamino)propanoate

: 60331-03-5
4-chloro-2,6-dimethoxy-5-nitropyrimidine

: 1398113-56-8
methyl 3-((2,6-dimethoxy-5-nitropyrimidin-4-yl)(phenyl)amino)propanoate

Guidance literature:: In tert-butyl alcohol; for 8h; Reflux;
DOI:10.1016/j.tetlet.2012.06.143

Reference yield: 86.0%

: 1398113-56-8
methyl 3-((2,6-dimethoxy-5-nitropyrimidin-4-yl)(phenyl)amino)propanoate

: 1398113-58-0
2,4-dimethoxy-9-phenyl-8,9-dihydro-5H-pyrimido[4,5-b][1,4]diazepin-6(7H)-one

Guidance literature:: With sodium dithionite; In ethanol; water; for 6h; Reflux;
DOI:10.1016/j.tetlet.2012.06.143

Reference yield:

: 1398113-56-8
methyl 3-((2,6-dimethoxy-5-nitropyrimidin-4-yl)(phenyl)amino)propanoate

: 1398113-69-3
1-(ethoxymethyl)-5-methyl-9-phenyl-8,9-dihydro-1H-pyrimido[4,5-b][1,4]diazepine-2,4,6(3H,5H,7H)-trione

Guidance literature:: Multi-step reaction with 4 steps

1: sodium dithionite / ethanol; water / 6 h / Reflux

2: sodium hydride / tetrahydrofuran; mineral oil / 0.25 h / 20 °C

3: chloro-trimethyl-silane; sodium iodide / acetonitrile / 24 h / 20 °C / Inert atmosphere

4: N,O-bis-(trimethylsilyl)-acetamide / chloroform

With chloro-trimethyl-silane; sodium dithionite; N,O-bis-(trimethylsilyl)-acetamide; sodium hydride; sodium iodide; In tetrahydrofuran; ethanol; chloroform; water; acetonitrile; mineral oil;
DOI:10.1016/j.tetlet.2012.06.143