2-PHENYL-1,3-OXAZOLE

Base Information

• Chemical Name: 2-PHENYL-1,3-OXAZOLE
• CAS No.: 20662-88-8
• Molecular Formula: C9H7 N O
• Molecular Weight: 145.161
• Hs Code.: 2934999090
• Mol file: 20662-88-8.mol

Synonyms:2-Phenyloxazole

Chemical Property of 2-PHENYL-1,3-OXAZOLE

Chemical Property:

• Vapor Pressure: 0.0406mmHg at 25°C
• Refractive Index: 1.543
• Boiling Point: 247.3°Cat760mmHg
• PKA: 0.91±0.10(Predicted)
• Flash Point: 96°C
• PSA: 26.03000
• Density: 1.11g/cm³
• LogP: 2.34160

Purity/Quality:

HPLC≥98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-PHENYL-1,3-OXAZOLE

There total 53 articles about 2-PHENYL-1,3-OXAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

2-phenyl-1,3-oxazoline (7127-19-7) → 2-phenyloxazole (20662-88-8)

Guidance literature:

With methanol; manganese(IV) oxide; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In nitromethane; at 80 ℃; for 48h; Inert atmosphere;

DOI:10.1021/ol102078v

Reference yield: 85.6%

phenylzinc chloride (28557-00-8) + 2-(methylthio)oxazole (201017-90-5) → 2-phenyloxazole (20662-88-8)

Guidance literature:

With bis(triphenylphosphine)nickel(II) chloride; In tetrahydrofuran; at 60 - 65 ℃; for 6h; Inert atmosphere;

DOI:10.1021/ol900260g

Reference yield: 84.0%

N-(endo-2-hydroxybicyclo<2.2.1>hept-5-en-3-endo-yl)benzamide → 2-phenyloxazole (20662-88-8)

Guidance literature:

In decalin; at 195 ℃; for 5h;

DOI:10.1021/jo00064a029

upstream raw materials:

4-(1,3-oxazol-2-yl)aniline

2-(o-aminophenyl)oxazole

2-phenyl-1,3-oxazole-4-carboxylic acid

4-(4-methoxy-phenyl)-5-phenyl-oxazole

Downstream raw materials:

2-phenyl-3-methyloxazolium iodide

N-(2-hydroxyethyl)-benzamide

C₁₃H₁₃NO₄

butyl (E)-3-(2-phenyloxazol-5-yl)acrylate

Refernces

• 1、 Baba, Daisuke,Fuchigami, Toshio. "Anodic methoxylation and acetoxylation of imines and imidates". . p. 3133 - 3136. Retrieved 2003.
• 2、 Shi, Xinzhe,Soulé, Jean-Fran?ois,Doucet, Henri. "Reaction Conditions for the Regiodivergent Direct Arylations at C2- or C5-Positions of Oxazoles using Phosphine-Free Palladium Catalysts". . p. 4748 - 4760. Retrieved 2019/09/12.
• 3、 ?agud, Ivana,?indler-Kulyk, Marija,Vojnovi?-Jandri?, Dragana,Marini?, ?eljko. "Versatile Photochemical Reactivity of Diverse Substituted 2-, 4- and 5-(o-Vinylstyryl)oxazoles". . p. 515 - 524. Retrieved 2018/02/09.