4-(4-Methoxyphenyl)-5-phenyl-1,3-oxazole

Base Information

• Chemical Name: 4-(4-Methoxyphenyl)-5-phenyl-1,3-oxazole
• CAS No.: 62921-40-8
• Molecular Formula: C₁₆H₁₃NO₂
• Molecular Weight: 251.285
• DSSTox Substance ID: DTXSID20490424
• Wikidata: Q82334189
• Mol file: 62921-40-8.mol

Synonyms:4-(4-Methoxyphenyl)-5-phenyl-1,3-oxazole;62921-40-8;DTXSID20490424

Chemical Property of 4-(4-Methoxyphenyl)-5-phenyl-1,3-oxazole

Chemical Property:

• XLogP3: 3.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 251.094628657
• Heavy Atom Count: 19
• Complexity: 270

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C2=C(OC=N2)C3=CC=CC=C3

Technology Process of 4-(4-Methoxyphenyl)-5-phenyl-1,3-oxazole

There total 2 articles about 4-(4-Methoxyphenyl)-5-phenyl-1,3-oxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(4-methoxyphenyl)-5-phenyl oxazole (17064-22-1) → 4-(4-methoxy-phenyl)-5-phenyl-oxazole (62921-40-8)

Guidance literature:

In ethanol; for 46h; Heating; Irradiation;

DOI:10.1039/P19770000239

Reference yield:

formic acid (64-18-6) + 4-Methoxyphenyl α-chlorobenzyl ketone (62921-41-9) → 4-(4-methoxy-phenyl)-5-phenyl-oxazole (62921-40-8)

Guidance literature:

With ammonium formate;

DOI:10.1039/P19770000239

Reference yield:

4-(4-methoxy-phenyl)-5-phenyl-oxazole (62921-40-8) → 2-phenyloxazole (20662-88-8)

Guidance literature:

With oxygen; In ethanol; for 9h; Heating; Irradiation;

DOI:10.1039/P19770000239

upstream raw materials:

formic acid

4-Methoxyphenyl α-chlorobenzyl ketone

2-(4-methoxyphenyl)-5-phenyl oxazole

Downstream raw materials:

2-phenyloxazole

3-phenylisoxazole