[3-(2-Amino-ethoxy)-benzyl]-((E)-6,6-dimethyl-hept-2-en-4-ynyl)-ethyl-amine

Base Information

• Chemical Name: [3-(2-Amino-ethoxy)-benzyl]-((E)-6,6-dimethyl-hept-2-en-4-ynyl)-ethyl-amine
• CAS No.: 159554-47-9
• Molecular Formula: C₂₀H₃₀N₂O
• Molecular Weight: 314.471
• Mol file: 159554-47-9.mol

Synonyms:[3-(2-Amino-ethoxy)-benzyl]-((E)-6,6-dimethyl-hept-2-en-4-ynyl)-ethyl-amine

Chemical Property of [3-(2-Amino-ethoxy)-benzyl]-((E)-6,6-dimethyl-hept-2-en-4-ynyl)-ethyl-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [3-(2-Amino-ethoxy)-benzyl]-((E)-6,6-dimethyl-hept-2-en-4-ynyl)-ethyl-amine

There total 2 articles about [3-(2-Amino-ethoxy)-benzyl]-((E)-6,6-dimethyl-hept-2-en-4-ynyl)-ethyl-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

(3-{[((E)-6,6-Dimethyl-hept-2-en-4-ynyl)-ethyl-amino]-methyl}-phenoxy)-acetonitrile (159554-45-7) → [3-(2-Amino-ethoxy)-benzyl]-((E)-6,6-dimethyl-hept-2-en-4-ynyl)-ethyl-amine (159554-47-9)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; at 0 ℃; for 2h;

DOI:10.1016/S0960-894X(98)00213-3

Reference yield:

(E)-N-ethyl-N-(6,6-dimethyl-2-hepten-4-ynyl)-3-hydroxybenzylamine (123944-74-1) → [3-(2-Amino-ethoxy)-benzyl]-((E)-6,6-dimethyl-hept-2-en-4-ynyl)-ethyl-amine (159554-47-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / K₂CO₃ / dimethylformamide / 16 h / 80 °C

2: 50 percent / LiAlH₄ / tetrahydrofuran / 1 h / 0 °C

With lithium aluminium tetrahydride; potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide; 1: Alkylation / 2: Reduction;

Reference yield: 70.0%

thiophen-3-yl-acetic acid (6964-21-2) + [3-(2-Amino-ethoxy)-benzyl]-((E)-6,6-dimethyl-hept-2-en-4-ynyl)-ethyl-amine (159554-47-9) → N-[2-(3-{[(6,6-dimethyl-hept-2-en-4-ynyl)-ethyl-amino]-methyl}-phenoxy)-ethyl]-2-thiophen-3-yl-acetamide

Guidance literature:

With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 16h;

upstream raw materials:

(3-{[((E)-6,6-Dimethyl-hept-2-en-4-ynyl)-ethyl-amino]-methyl}-phenoxy)-acetonitrile

(E)-N-ethyl-N-(6,6-dimethyl-2-hepten-4-ynyl)-3-hydroxybenzylamine