(3-{[((E)-6,6-Dimethyl-hept-2-en-4-ynyl)-ethyl-amino]-methyl}-phenoxy)-acetonitrile

Base Information

• Chemical Name: (3-{[((E)-6,6-Dimethyl-hept-2-en-4-ynyl)-ethyl-amino]-methyl}-phenoxy)-acetonitrile
• CAS No.: 159554-45-7
• Molecular Formula: C₂₀H₂₆N₂O
• Molecular Weight: 310.439
• Mol file: 159554-45-7.mol

Synonyms:(3-{[((E)-6,6-Dimethyl-hept-2-en-4-ynyl)-ethyl-amino]-methyl}-phenoxy)-acetonitrile

Chemical Property of (3-{[((E)-6,6-Dimethyl-hept-2-en-4-ynyl)-ethyl-amino]-methyl}-phenoxy)-acetonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3-{[((E)-6,6-Dimethyl-hept-2-en-4-ynyl)-ethyl-amino]-methyl}-phenoxy)-acetonitrile

There total 1 articles about (3-{[((E)-6,6-Dimethyl-hept-2-en-4-ynyl)-ethyl-amino]-methyl}-phenoxy)-acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

(E)-N-ethyl-N-(6,6-dimethyl-2-hepten-4-ynyl)-3-hydroxybenzylamine (123944-74-1) + cyanomethyl bromide (590-17-0) → (3-{[((E)-6,6-Dimethyl-hept-2-en-4-ynyl)-ethyl-amino]-methyl}-phenoxy)-acetonitrile (159554-45-7)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 16h;

Reference yield: 75.0%

(3-{[((E)-6,6-Dimethyl-hept-2-en-4-ynyl)-ethyl-amino]-methyl}-phenoxy)-acetonitrile (159554-45-7) → [3-(2-Amino-ethoxy)-benzyl]-((E)-6,6-dimethyl-hept-2-en-4-ynyl)-ethyl-amine (159554-47-9)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; at 0 ℃; for 2h;

DOI:10.1016/S0960-894X(98)00213-3

Reference yield:

(3-{[((E)-6,6-Dimethyl-hept-2-en-4-ynyl)-ethyl-amino]-methyl}-phenoxy)-acetonitrile (159554-45-7) → Thiophene-2-sulfonic acid [2-(3-{[((E)-6,6-dimethyl-hept-2-en-4-ynyl)-ethyl-amino]-methyl}-phenoxy)-ethyl]-amide

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / LiAlH₄ / diethyl ether / 2 h / 0 °C

2: 60 percent / Et₃N / CH₂Cl₂ / 1 h / Ambient temperature

With lithium aluminium tetrahydride; triethylamine; In diethyl ether; dichloromethane;

DOI:10.1016/S0960-894X(98)00213-3

upstream raw materials:

(E)-N-ethyl-N-(6,6-dimethyl-2-hepten-4-ynyl)-3-hydroxybenzylamine

cyanomethyl bromide

Downstream raw materials:

[3-(2-Amino-ethoxy)-benzyl]-((E)-6,6-dimethyl-hept-2-en-4-ynyl)-ethyl-amine