(Z)-3-(3-(3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylic (isobutyl carbonic) anhydride

Base Information

Chemical Name:(Z)-3-(3-(3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylic (isobutyl carbonic) anhydride
CAS No.:1388842-52-1
Molecular Formula:C₁₈H₁₅F₆N₃O₄
Molecular Weight:451.325
Hs Code.:

Synonyms:(Z)-3-(3-(3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylic (isobutyl carbonic) anhydride

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Chemical Property of (Z)-3-(3-(3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylic (isobutyl carbonic) anhydride

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Technology Process of (Z)-3-(3-(3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylic (isobutyl carbonic) anhydride

There total 5 articles about (Z)-3-(3-(3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylic (isobutyl carbonic) anhydride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1388842-44-1
(Z)-3-(3-(3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylic acid

: 543-27-1
isobutyl chloroformate

: 1388842-52-1
(Z)-3-(3-(3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylic (isobutyl carbonic) anhydride

Guidance literature:: With 4-methyl-morpholine; In tetrahydrofuran; at 0 ℃; for 0.5h;

Reference yield:

: 1333154-10-1
3-(3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazole

: 1388842-52-1
(Z)-3-(3-(3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylic (isobutyl carbonic) anhydride

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1,4-diaza-bicyclo[2.2.2]octane / N,N-dimethyl-formamide / 0.5 h

1.2: 1 h

2.1: lithium hydroxide; water / tetrahydrofuran / 4 h / 20 °C

3.1: tetrahydrofuran; 1-methyl-pyrrolidin-2-one / 1 h / -10 °C

With 1,4-diaza-bicyclo[2.2.2]octane; water; lithium hydroxide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide;

Reference yield:

: 1333152-22-9
(Z)-isopropyl 3-(3-(3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylate

: 1388842-52-1
(Z)-3-(3-(3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylic (isobutyl carbonic) anhydride

Guidance literature:: Multi-step reaction with 2 steps

1: lithium hydroxide; water / tetrahydrofuran / 4 h / 20 °C

2: tetrahydrofuran; 1-methyl-pyrrolidin-2-one / 1 h / -10 °C

With water; lithium hydroxide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one;