1333152-22-9

Usage

Uses

Used in Pharmaceutical Synthesis:
(Z)-isopropyl 3-(3-(3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylate is used as a building block in the synthesis of pharmaceuticals for its unique chemical properties and potential to contribute to the development of new drugs.
Used in Agrochemical Development:
In the agrochemical industry, (Z)-isopropyl 3-(3-(3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylate is utilized as a component in the creation of new agrochemicals, leveraging its stability and reactivity to enhance crop protection products.
Used in Material Science:
(Z)-isopropyl 3-(3-(3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylate is employed as a key component in the development of new materials, taking advantage of its thermal stability and chemical structure to improve material performance in various applications.
Safety and Handling:
It is crucial to handle and store (Z)-isopropyl 3-(3-(3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylate safely, as it may pose hazards to human health and the environment if not managed properly. Proper safety measures should be implemented to mitigate any risks associated with its use.

Upstream product

• 1333154-10-1 3-(3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazole 
• 1333154-26-9 (Z)-isopropyl 3-iodoacrylate 
• 96088-62-9 isopropyl propiolate 
• 317319-15-6 3,5-bis(trifluoromethyl)benzothioamide 
• 27126-93-8 3,5-bis(trifluoromethyl)benzonitrile 

Downstream Products

• 1421919-75-6 (Z)-3-(3-(3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)-1-(3,3-difluoroazetidin-1-yl)prop-2-en-1-one 
• 1388842-44-1 (Z)-3-(3-(3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylic acid 
• 1393477-72-9 3-[3-[3,5-bis(trifloromoethyl)phenyl]-1H-1,2,4-triazol-1-yl]-N’-(pyrazin-2-yl)acrylohydrazide 
• 1392136-43-4 (Z)-3-[3-[3,5-bis(trifluoromethyl)phenyl]-1,2,4-triazol-1-yl]-N'-pyridin-2-ylprop-2-enehydrazide 
• 1421920-37-7 C₁₈H₁₆F₆N₄O₂ 
• 1421923-74-1 C₁₇H₁₅F₆N₅O 
• 1421923-75-2 C₁₉H₁₄F₆N₆O 
• 1421923-76-3 C₁₈H₁₃F₆N₇O 
• 1421923-79-6 C₁₉H₁₄F₆N₆O 
• 1421923-80-9 C₁₇H₁₀ClF₆N₇O 
• 1421923-81-0 C₁₈H₁₂F₆N₆O 
• 1421923-82-1 C₂₁H₁₃F₆N₇O 
• 1421923-83-2 C₁₇H₁₅F₆N₅O₃S 
• 1421923-84-3 C₁₉H₁₉F₆N₅O 

Relevant academic research and scientific papers

Acryloyl group-containing nuclear transport modulator and uses thereof

The invention relates to a novel acryloyl-containing compound as well as a preparation method and application thereof. Specifically, the invention relates to an acryloyl-containing compound as shown in a formula (1) and a preparation method thereof, and a

SOLID FORMS OF SELINEXOR AND PROCESS FOR THEIR PREPARATION

Aspects of the present application relate to solid forms of Selinexor, processes for their preparation and pharmaceutical compositions thereof. Specific aspects relate to crystalline and amorphous forms of Selinexor.

NUCLEAR TRANSPORT MODULATORS AND USES THEREOF

The present invention relates to compounds of Structural Formulas (I), (II) and (III): or their pharmaceutically acceptable salts; pharmaceutical compositions comprising the compounds of Structural Formulas (I), (II) and (III); and methods of using said compounds, salts and compositions in the treatment of various disorders associated with CRMl activity. The values for the variables in Structural Formulas (I), (II) and (III) are as described and defined herein.

HYDRAZIDE CONTAINING NUCLEAR TRANSPORT MODULATORS AND USES THEREOF

The invention generally relates to nuclear transport modulators, e.g., CRM1 inhibitors, and more particularly to a compound represented by structural formula (I): or a pharmaceutically acceptable salt thereof, wherein the values and alternative values for the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of structural formula I, or a pharmaceutically acceptable salt or composition thereof, e.g., in the treatment, modulation and/or prevention of physiological conditions associated with CRM1 activity.

NUCLEAR TRANSPORT MODULATORS AND USES THEREOF

The present invention relates to compounds of formula I: and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising the compounds of formula I, and methods of using said compounds, salts and compositions in the treatment of various disorders associated with CRM1 activity.

NUCLEAR TRANSPORT MODULATIORS AND USES THEREOF

The invention generally relates to the field of nuclear transport modulators, e.g., CRM1 inhibitors, and more particularly to new substituted-heterocyclic azole compounds, the synthesis and use of these compounds and their pharmaceutical compositions, e.g