ethyl 3-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-5-oxo-1-(2,2,2-trifluoroethyl)prolinate

Base Information

Chemical Name:ethyl 3-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-5-oxo-1-(2,2,2-trifluoroethyl)prolinate
CAS No.:1301660-85-4
Molecular Formula:C₃₄H₃₁F₁₀N₃O₄
Molecular Weight:735.622
Hs Code.:

ethyl 3-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-5-oxo-1-(2,2,2-trifluoroethyl)prolinate

Synonyms:ethyl 3-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-5-oxo-1-(2,2,2-trifluoroethyl)prolinate

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Chemical Property of ethyl 3-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-5-oxo-1-(2,2,2-trifluoroethyl)prolinate

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Technology Process of ethyl 3-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-5-oxo-1-(2,2,2-trifluoroethyl)prolinate

There total 8 articles about ethyl 3-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-5-oxo-1-(2,2,2-trifluoroethyl)prolinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 23199-56-6
2,2,2-trifluoroethyltrichloromethanesulfonate

: 1301660-80-9
ethyl 3-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-5-oxoprolinate

: 1301660-85-4
ethyl 3-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-5-oxo-1-(2,2,2-trifluoroethyl)prolinate

Guidance literature:: ethyl 3-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-5-oxoprolinate; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at -35 ℃; for 0.25h; Inert atmosphere;

2,2,2-trifluoroethyltrichloromethanesulfonate; In N,N-dimethyl-formamide; mineral oil; at 20 ℃;

Reference yield:

: 825643-73-0
2-(3,5-bis(trifluoromethyl)phenyl)-N-(6-chloro-4-(4-fluoro-2-methylphenyl)pyridin-3-yl)-N,2-dimethylpropanamide

: 1301660-85-4
ethyl 3-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-5-oxo-1-(2,2,2-trifluoroethyl)prolinate

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 8 h / Reflux

2.1: osmium(VIII) oxide; water / tetrahydrofuran / 0.5 h / 20 °C

2.2: 4 h / 20 °C

3.1: toluene / 2 h / Reflux

4.1: sodium ethanolate / ethanol; dimethyl sulfoxide / 0.5 h / 20 °C

4.2: 18 h / 110 °C

5.1: sodium hydroxide; water / methanol / 18 h / 20 °C

6.1: toluene; dimethyl sulfoxide / 3 h / 100 °C

7.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / -35 °C / Inert atmosphere

7.2: 20 °C

With osmium(VIII) oxide; water; sodium ethanolate; sodium hydride; sodium carbonate; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; mineral oil; 1.1: Suzuki Coupling;

Reference yield:

: 1263187-14-9
3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-acrylic acid ethyl ester

: 1301660-85-4
ethyl 3-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-5-oxo-1-(2,2,2-trifluoroethyl)prolinate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane; ethanol; water / 0.33 h / 140 °C / Microwave irradiation

2.1: sodium ethanolate / ethanol; dimethyl sulfoxide / 0.5 h / 20 °C

2.2: 18 h / 110 °C

3.1: sodium hydroxide; water / methanol / 18 h / 20 °C

4.1: toluene; dimethyl sulfoxide / 3 h / 100 °C

5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / -35 °C / Inert atmosphere

5.2: 20 °C

With water; sodium ethanolate; sodium hydride; sodium carbonate; sodium hydroxide; bis-triphenylphosphine-palladium(II) chloride; In methanol; 1,2-dimethoxyethane; ethanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; mineral oil; 1.1: Suzuki Coupling;