23199-56-6

Usage

Uses

Used in Synthetic Organic Chemistry:
2,2,2-Trifluoroethyl trichloromethanesulfonate is used as a coupling agent for various synthetic organic chemistry applications. Its role as a powerful alkylating agent allows it to facilitate the formation of new carbon-carbon or carbon-heteroatom bonds, which are essential in the synthesis of complex organic molecules.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2,2,2-Trifluoroethyl trichloromethanesulfonate is utilized as a key intermediate in the synthesis of certain drugs. Its reactivity enables the creation of new drug molecules with potential therapeutic applications.
Used in Chemical Research:
2,2,2-Trifluoroethyl trichloromethanesulfonate is also employed in chemical research as a tool to study the reactivity of various nucleophiles and to understand the mechanisms of alkylation reactions. This knowledge can be applied to develop new synthetic strategies and improve existing ones.

InChI:InChI=1/C3H2Cl3F3O3S/c4-3(5,6)13(10,11)12-1-2(7,8)9/h1H2

Upstream product

• 2547-61-7 Trichloromethanesulfonyl chloride 
• 75-89-8 2,2,2-trifluoroethanol 

Downstream Products

• 22753-82-8 4-chloro-N-(2,2,2-trifluoroethyl)benzenamine 
• 22753-80-6 5-chloro-2-[(2,2,2-trifluoroethyl)amino]benzophenone 
• 351-97-3 4-nitro-N-(2,2,2-trifluoroethyl)aniline 
• 50939-39-4 5-chloro-2'-fluoro-2-(N-(2,2,2-trifluoroethyl)amino)benzophenon 
• 50885-15-9 (2-Chloro-phenyl)-[5-chloro-2-(2,2,2-trifluoro-ethylamino)-phenyl]-methanone 
• 50885-29-5 4-bromo-N-(2,2,2-trifluoroethyl)benzenamine 
• 50885-16-0 Phenyl-[2-(2,2,2-trifluoro-ethylamino)-phenyl]-methanone 
• 50885-17-1 2-(2,2,2-trifluoroethylamino)-5-nitrobenzophenone 
• 62894-31-9 4,5-bis-(4-chloro-phenyl)-2-(2,2,2-trifluoro-ethylsulfanyl)-1H-imidazole 
• 62894-28-4 4,5-bis-(4-methoxy-phenyl)-2-(2,2,2-trifluoro-ethylsulfanyl)-1H-imidazole 
• 62894-25-1 4,5-diphenyl-2-<(2,2,2-trifluoroethyl)thio>imidazole 
• 784156-90-7 benzyl 6-[(tert-butoxycarbonyl)amino]-5-oxo-4-(2,2,2-trifluoroethyl)-1,4-diazepane-1-carboxylate 
• 80054-80-4 1-chloro-4-(2,2,2-trifluoroethoxy)benzene 
• 920974-11-4 2-chloro-N-(2,2,2-trifluoroethyl)-N-[4-(1,1,1-trifluoro-2-hydroxypropan-2-yl)phenyl]benzenesulfonamide 

Relevant academic research and scientific papers

Synthesis and Structural Requirements of N-Substituted Norapomorphines for Affinity and Activity at Dopamine D-1, D-2, and Agonist Receptor Sites in Rat Brain

A series of N-substituted analogues of (R)-(-)-naorapomorphine were synthesized to study the optimal structural requirements of the N-alkyl side chain to interact with D-1 and D-2 dopaminergic receptors as well as dopamine (DA) agonist binding sites.Evaluation included testing the affinity of these compounds for DA receptor sites in rat striatal tissue and assessing stereotypy as a behavioral index of dopaminergic activity.The electronic, steric, and lipohilic properties of the N-alkyl side chain were found to be related to affinity, D-2 selectivity, and dopaminergic activity.All 11 compounds evaluated had relatively low affinity at D-1 sites.Optimum D-2 and agonist-site affinity as well as agonist activity were exhibited by N-cyclopropylmethyl (7) N-allyl N-propyl (4) or N-ethyl (3) substituted compounds.Branching of the N-alkyl side chain as in N-isopropyl (5) and N-isobutyl (6) markedly reduced the D-2 affinity and activity, presumably due to steric effects.The N-trifluoroethyl (10) and N-pentafluoropropyl (11) derivatives had low affinity for all their dopamine receptor sites and no agonistic activity; evidently, the highly electronegative F atoms decrease basicity of the N atom and therefore decrease the ability of the N atom to be cationic at physiological pH, a proposed requirement for high-affinity binding to DA receptors.

1-POLYHALOGENOALKYL-2-OXO-1,3-DIHYDRO-2H-1,4-BENZODIAZEPINES

This invention relates to 2-oxo-1,3-dihydro-2H-1,4-dibenziodiazepines, and the 4-N-oxides thereof, having a polyfluoroalkyl radical attached at the 1-position thereof, to their use as muscle relaxants, as sedatives, an anticonvulsants, and as anti-anxiety agents and to the intermediates useful in the preparation thereof. The compounds may be prepared by N-polyfluoroalkylating the appropriately substituted 2-oxo-1,3-dihydro-2H-1,4-benzodiazepines. Alternate methods for the synthesis of the compounds of this invention are also described