5-chloropyridin-3-yl 1-((3-nitrophenyl)sulfonyl)-1H-indole-5-carboxylate

Base Information

Chemical Name:5-chloropyridin-3-yl 1-((3-nitrophenyl)sulfonyl)-1H-indole-5-carboxylate
CAS No.:1087243-10-4
Molecular Formula:C₂₀H₁₂ClN₃O₆S
Molecular Weight:457.851
Hs Code.:

Synonyms:5-chloropyridin-3-yl 1-((3-nitrophenyl)sulfonyl)-1H-indole-5-carboxylate

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Chemical Property of 5-chloropyridin-3-yl 1-((3-nitrophenyl)sulfonyl)-1H-indole-5-carboxylate

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Technology Process of 5-chloropyridin-3-yl 1-((3-nitrophenyl)sulfonyl)-1H-indole-5-carboxylate

There total 4 articles about 5-chloropyridin-3-yl 1-((3-nitrophenyl)sulfonyl)-1H-indole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 74115-12-1
5-chloropyridin-3-ol

: 1087243-34-2
C₁₅H₁₀N₂O₆S

: 1087243-10-4
5-chloropyridin-3-yl 1-((3-nitrophenyl)sulfonyl)-1H-indole-5-carboxylate

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 23 ℃;
DOI:10.1016/j.bmcl.2008.08.082

Reference yield:

: 1011-65-0
5-methoxycarbonylindole

: 1087243-10-4
5-chloropyridin-3-yl 1-((3-nitrophenyl)sulfonyl)-1H-indole-5-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydride / tetrahydrofuran; mineral oil / 10 h / 0 - 23 °C / Inert atmosphere

2: lithium hydroxide / water; tetrahydrofuran / 9 h / 23 °C / Inert atmosphere

3: 1,2-dichloro-ethane; dmap / dichloromethane / 5 h / 23 °C / Inert atmosphere

With dmap; sodium hydride; 1,2-dichloro-ethane; lithium hydroxide; In tetrahydrofuran; dichloromethane; water; mineral oil;
DOI:10.1021/acs.jmedchem.1c01214

Reference yield:

: 1087243-30-8
C₁₆H₁₂N₂O₆S

: 1087243-10-4
5-chloropyridin-3-yl 1-((3-nitrophenyl)sulfonyl)-1H-indole-5-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: lithium hydroxide / water; tetrahydrofuran / 9 h / 23 °C / Inert atmosphere

2: 1,2-dichloro-ethane; dmap / dichloromethane / 5 h / 23 °C / Inert atmosphere

With dmap; 1,2-dichloro-ethane; lithium hydroxide; In tetrahydrofuran; dichloromethane; water;
DOI:10.1021/acs.jmedchem.1c01214