methyl 2-((tert-butoxycarbonyl)amino)-2-(3-hydroxyphenyl)acetate

Base Information

• Chemical Name: methyl 2-((tert-butoxycarbonyl)amino)-2-(3-hydroxyphenyl)acetate
• CAS No.: 526217-60-7
• Molecular Formula: C₁₄H₁₉NO₅
• Molecular Weight: 281.309
• Mol file: 526217-60-7.mol

Synonyms:methyl 2-((tert-butoxycarbonyl)amino)-2-(3-hydroxyphenyl)acetate

Chemical Property of methyl 2-((tert-butoxycarbonyl)amino)-2-(3-hydroxyphenyl)acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2-((tert-butoxycarbonyl)amino)-2-(3-hydroxyphenyl)acetate

There total 3 articles about methyl 2-((tert-butoxycarbonyl)amino)-2-(3-hydroxyphenyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

(RS)-3-Hydroxyphenylglycine + di-tert-butyl dicarbonate (24424-99-5) → methyl 2-((tert-butoxycarbonyl)amino)-2-(3-hydroxyphenyl)acetate (526217-60-7)

Guidance literature:

(RS)-3-Hydroxyphenylglycine; With thionyl chloride; In methanol; at 80 ℃; for 2h;

di-tert-butyl dicarbonate; With triethylamine; In methanol; dichloromethane; at 20 ℃; for 21h;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + methyl amino(3-hydroxyphenyl)acetate (130697-96-0) → methyl 2-((tert-butoxycarbonyl)amino)-2-(3-hydroxyphenyl)acetate (526217-60-7)

Guidance literature:

In chloroform; at 20 ℃; for 5h;

DOI:10.1016/S0968-0896(02)00380-2

Reference yield:

D-α-amino-m-hydroxyphenylacetic acid (31932-87-3) → methyl 2-((tert-butoxycarbonyl)amino)-2-(3-hydroxyphenyl)acetate (526217-60-7)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / 2 h / 80 °C

2: triethylamine; sodium hydrogencarbonate / methanol; dichloromethane / 21 h / 20 °C

With thionyl chloride; sodium hydrogencarbonate; triethylamine; In methanol; dichloromethane;

upstream raw materials:

di-tert-butyl dicarbonate

methyl amino(3-hydroxyphenyl)acetate

D-α-amino-m-hydroxyphenylacetic acid

Downstream raw materials:

tert-butyl (2-hydroxy-1-(3-hydroxyphenyl)ethyl)carbamate

tert-butyl (1-(3-(benzyloxy)phenyl)-2-hydroxyethyl)carbamate

2-(3-(benzyloxy)phenyl)-2-((tert-butoxycarbonyl)amino)ethyl methanesulfonate

(RS)-tert-butoxycarbonylamino-[3-(tetrahydropyran-4-yloxy)phenyl]acetic acid methyl ester