31932-87-3

Usage

Uses

(RS)-3-Hydroxyphenylglycine is an agonist at PI-linked metabotropic glutamate receptors.

InChI:1S/C8H9NO3/c9-7(8(11)12)5-2-1-3-6(10)4-5/h1-4,7,10H,9H2,(H,11,12)

Upstream product

• 2835-06-5 phenylglycin 
• 7314-43-4 D-α-amino-m-methoxyphenylacetic acid 

Downstream Products

• 33130-90-4 DL-2-N-tert-butoxycarbonylamino-2-(3-hydroxyphenyl)acetic acid 
• 526217-60-7 methyl 2-((tert-butoxycarbonyl)amino)-2-(3-hydroxyphenyl)acetate 
• 1454273-67-6 tert-butyl (2-hydroxy-1-(3-hydroxyphenyl)ethyl)carbamate 
• 913523-95-2 tert-butyl (1-(3-(benzyloxy)phenyl)-2-hydroxyethyl)carbamate 
• 1454273-68-7 2-(3-(benzyloxy)phenyl)-2-((tert-butoxycarbonyl)amino)ethyl methanesulfonate 
• 130697-96-0 methyl amino(3-hydroxyphenyl)acetate 

Relevant academic research and scientific papers

Mutasynthesis of Glycopeptide Antibiotics: Variations of Vancomycin's AB-Ring Amino Acid 3,5-Dihydroxyphenylglycine

In the mutasynthetic approach, the ΔdpgA mutant of the vancomycin-type glycopeptide antibiotic producer Amycolatopsis balhimycina, which is deficient in the synthesis of 3,5-dihydroxyphenylglycine (DPg), was supplemented with synthetic DPg analogues to obtain the corresponding modified glycopeptides. Sterically more demanding 3,5-disubstituted methoxy derivatives as well as monosubstituted DPg analogues were accepted as substrates. These facts indicate that steric and electronic requirements suffice in several cases for the oxidative closure of the AB ring, thus leading to the generation of novel antibiotically active glycopeptide derivatives. The results represent a further step in evaluating the potential of mutasynthesis for peptidic secondary metabolites. Copyright

HYDROXYLATION OF AROMATIC RINGS IN AN AQUEOUS SOLUTION INDUCED BY ARGON ARC PLASMA

Plasma-induced reaction in an aqueous solution of phenyl-containing amino acids resulted in the formation of several hydroxyphenyl amino acids, which was explained by the action of hydroxyl radicals generated by decomposition of water molecules by the high energy plasma.

HYDROXYLATION REACTION OF AROMATIC RINGS IN AQUEOUS SOLUTION INDUCED BY HYDROGEN-OXYGEN FLAME

It was found that direct hydroxylation of aromatic rings proceeded in aqueous solution of phenyl-containing amino acids by using hydrogen-oxygen flame and that the active species of the reaction could be considered as hydroxyl radicals generated in the burning flame.

7-α-Amino-substituted acylamino-3-(1-carboxymethyltetrazol-5-ylthiomethyl)-3-cephem-4-carboxylic acids

Certain 7-acylamido-3-(1-carboxy-loweralkyl-tetrazol-5-ylthiomethyl)-3-cephem-4-carboxylic acids and their salts and easily hydrolyzed esters of the 4-carboxyl group were synthesized and found to be potent antibacterial agents which exhibited good aqueous solubility. In a preferred embodiment the 7-substituent was 2'-aminomethylphenylacetamido.