5-(4-((3-(6-(3-hydroxy-3-methylbutoxy)-4-methylpyridin-3-yl)-2-methylphenyl)methoxy)phenyl)isoxazol-3-ol

Base Information

Chemical Name:5-(4-((3-(6-(3-hydroxy-3-methylbutoxy)-4-methylpyridin-3-yl)-2-methylphenyl)methoxy)phenyl)isoxazol-3-ol
CAS No.:1294453-66-9
Molecular Formula:C₂₈H₃₀N₂O₅
Molecular Weight:474.557
Hs Code.:

Synonyms:5-(4-((3-(6-(3-hydroxy-3-methylbutoxy)-4-methylpyridin-3-yl)-2-methylphenyl)methoxy)phenyl)isoxazol-3-ol

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Chemical Property of 5-(4-((3-(6-(3-hydroxy-3-methylbutoxy)-4-methylpyridin-3-yl)-2-methylphenyl)methoxy)phenyl)isoxazol-3-ol

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Technology Process of 5-(4-((3-(6-(3-hydroxy-3-methylbutoxy)-4-methylpyridin-3-yl)-2-methylphenyl)methoxy)phenyl)isoxazol-3-ol

There total 8 articles about 5-(4-((3-(6-(3-hydroxy-3-methylbutoxy)-4-methylpyridin-3-yl)-2-methylphenyl)methoxy)phenyl)isoxazol-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1294453-68-1
ethyl 3-(4-((3-(6-(3-hydroxy-3-methylbutoxy)-4-methylpyridin-3-yl)-2-methylphenyl)methoxy)phenyl)propiolate

: 1294453-66-9
5-(4-((3-(6-(3-hydroxy-3-methylbutoxy)-4-methylpyridin-3-yl)-2-methylphenyl)methoxy)phenyl)isoxazol-3-ol

Guidance literature:: With hydroxylamine; sodium hydroxide; In ethanol; water; for 1h; Reflux;

Reference yield:

: 17689-66-6
3-hydroxy-3-methylbutyl toluene-4-sulfonate

: 1294453-66-9
5-(4-((3-(6-(3-hydroxy-3-methylbutoxy)-4-methylpyridin-3-yl)-2-methylphenyl)methoxy)phenyl)isoxazol-3-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / Cooling with ice

1.2: 4 h / 60 °C

2.1: potassium phosphate / palladium diacetate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / toluene; water / 0.5 h / Reflux

2.2: 2 h / Reflux

3.1: tributylphosphine; diamide / water; tetrahydrofuran / 1 h / 20 °C / Cooling with ice

4.1: sodium hydroxide; hydroxylamine / ethanol; water / 1 h / Reflux

With potassium phosphate; tributylphosphine; diamide; hydroxylamine; sodium hydride; sodium hydroxide; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; toluene; mineral oil;

Reference yield:

: 83647-43-2
3-bromo-2-methylbenzyl alcohol

: 1294453-66-9
5-(4-((3-(6-(3-hydroxy-3-methylbutoxy)-4-methylpyridin-3-yl)-2-methylphenyl)methoxy)phenyl)isoxazol-3-ol

Guidance literature:: Multi-step reaction with 5 steps

1.1: pyridinium p-toluenesulfonate / dichloromethane / 1.5 h / 20 °C

2.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 1 h / Reflux

3.1: potassium phosphate / palladium diacetate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / toluene; water / 0.5 h / Reflux

3.2: 2 h / Reflux

4.1: tributylphosphine; diamide / water; tetrahydrofuran / 1 h / 20 °C / Cooling with ice

5.1: sodium hydroxide; hydroxylamine / ethanol; water / 1 h / Reflux

With potassium phosphate; tributylphosphine; diamide; hydroxylamine; potassium acetate; sodium hydroxide; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium diacetate; pyridinium p-toluenesulfonate; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; toluene;