ethyl 3-(4-((3-(6-(3-hydroxy-3-methylbutoxy)-4-methylpyridin-3-yl)-2-methylphenyl)methoxy)phenyl)propiolate

Base Information

Chemical Name:ethyl 3-(4-((3-(6-(3-hydroxy-3-methylbutoxy)-4-methylpyridin-3-yl)-2-methylphenyl)methoxy)phenyl)propiolate
CAS No.:1294453-68-1
Molecular Formula:C₃₀H₃₃NO₅
Molecular Weight:487.596
Hs Code.:

Synonyms:ethyl 3-(4-((3-(6-(3-hydroxy-3-methylbutoxy)-4-methylpyridin-3-yl)-2-methylphenyl)methoxy)phenyl)propiolate

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Chemical Property of ethyl 3-(4-((3-(6-(3-hydroxy-3-methylbutoxy)-4-methylpyridin-3-yl)-2-methylphenyl)methoxy)phenyl)propiolate

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Technology Process of ethyl 3-(4-((3-(6-(3-hydroxy-3-methylbutoxy)-4-methylpyridin-3-yl)-2-methylphenyl)methoxy)phenyl)propiolate

There total 7 articles about ethyl 3-(4-((3-(6-(3-hydroxy-3-methylbutoxy)-4-methylpyridin-3-yl)-2-methylphenyl)methoxy)phenyl)propiolate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 955931-17-6
(3-(6-(3-hydroxy-3-methylbutoxy)-4-methylpyridin-3-yl)-2-methylphenyl)methanol

: 1030828-84-2
3-(4-chlorophenyl)-2-propionic acid ethyl ester

: 1294453-68-1
ethyl 3-(4-((3-(6-(3-hydroxy-3-methylbutoxy)-4-methylpyridin-3-yl)-2-methylphenyl)methoxy)phenyl)propiolate

Guidance literature:: With tributylphosphine; diamide; In tetrahydrofuran; water; at 20 ℃; for 1h; Cooling with ice;

Reference yield:

: 17689-66-6
3-hydroxy-3-methylbutyl toluene-4-sulfonate

: 1294453-68-1
ethyl 3-(4-((3-(6-(3-hydroxy-3-methylbutoxy)-4-methylpyridin-3-yl)-2-methylphenyl)methoxy)phenyl)propiolate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / Cooling with ice

1.2: 4 h / 60 °C

2.1: potassium phosphate / palladium diacetate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / toluene; water / 0.5 h / Reflux

2.2: 2 h / Reflux

3.1: tributylphosphine; diamide / water; tetrahydrofuran / 1 h / 20 °C / Cooling with ice

With potassium phosphate; tributylphosphine; diamide; sodium hydride; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; In tetrahydrofuran; water; N,N-dimethyl-formamide; toluene; mineral oil;

Reference yield:

: 83647-43-2
3-bromo-2-methylbenzyl alcohol

: 1294453-68-1
ethyl 3-(4-((3-(6-(3-hydroxy-3-methylbutoxy)-4-methylpyridin-3-yl)-2-methylphenyl)methoxy)phenyl)propiolate

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridinium p-toluenesulfonate / dichloromethane / 1.5 h / 20 °C

2.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 1 h / Reflux

3.1: potassium phosphate / palladium diacetate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / toluene; water / 0.5 h / Reflux

3.2: 2 h / Reflux

4.1: tributylphosphine; diamide / water; tetrahydrofuran / 1 h / 20 °C / Cooling with ice

With potassium phosphate; tributylphosphine; diamide; potassium acetate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium diacetate; pyridinium p-toluenesulfonate; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; toluene;