(2S,4S)-4-(3-benzyloxy-5-fluorophenyl)-4-hydroxy-2-methyltetrahydropyran

Base Information

Chemical Name:(2S,4S)-4-(3-benzyloxy-5-fluorophenyl)-4-hydroxy-2-methyltetrahydropyran
CAS No.:146565-10-8
Molecular Formula:C₁₉H₂₁FO₃
Molecular Weight:316.372
Hs Code.:

Synonyms:(2S,4S)-4-(3-benzyloxy-5-fluorophenyl)-4-hydroxy-2-methyltetrahydropyran

Suppliers and Price of (2S,4S)-4-(3-benzyloxy-5-fluorophenyl)-4-hydroxy-2-methyltetrahydropyran

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2S,4S)-4-(3-benzyloxy-5-fluorophenyl)-4-hydroxy-2-methyltetrahydropyran

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2S,4S)-4-(3-benzyloxy-5-fluorophenyl)-4-hydroxy-2-methyltetrahydropyran

There total 7 articles about (2S,4S)-4-(3-benzyloxy-5-fluorophenyl)-4-hydroxy-2-methyltetrahydropyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: (2S,4R)-4-(5-fluoro-3-hydroxyphenyl)-4-methoxy-2-methyltetrahydropyran

: 146565-10-8
(2S,4S)-4-(3-benzyloxy-5-fluorophenyl)-4-hydroxy-2-methyltetrahydropyran

: 133813-44-2
(2S,4R)-4-<3-(benzyloxy)-5-fluorophenyl>-4-methoxy-2-methyl-3,4,5,6-tetrahydro-2H-pyran

Guidance literature:

Reference yield:

: 24581-03-1
(5E)-hepta-1,5-dien-4-ol

: 146565-10-8
(2S,4S)-4-(3-benzyloxy-5-fluorophenyl)-4-hydroxy-2-methyltetrahydropyran

Guidance literature:: Multi-step reaction with 6 steps

1: Ti(OiPr)4, tert-butyl hydroperoxide (TBHP), molecular sieves / CH₂Cl₂ / -20 °C

2: sodium bis(2-methoxyethoxy)aluminium hydride (red-Al) / toluene; tetrahydrofuran / 0 °C

3: O₃ / methanol / -20 °C

4: 1.) ethanolic HCl, 2.) Et₃SiCl, imidazole, 3.) Et₃SiH, TMSOTf

5: CrO₃ / acetone

6: 1.) n-BuLi / 1.) THF, -70 deg C

With 1H-imidazole; chromium(VI) oxide; titanium(IV) isopropylate; hydrogenchloride; triethylsilane; tert.-butylhydroperoxide; n-butyllithium; molecular sieve; triethylsilyl chloride; trimethylsilyl trifluoromethanesulfonate; ozone; sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; methanol; dichloromethane; acetone; toluene;
DOI:10.1021/jm00054a016

Reference yield:

: 81076-06-4
(2S,3R,4S)-(-)-2,3-Epoxy-6-hepten-4-ol

: 146565-10-8
(2S,4S)-4-(3-benzyloxy-5-fluorophenyl)-4-hydroxy-2-methyltetrahydropyran

Guidance literature:: Multi-step reaction with 5 steps

1: sodium bis(2-methoxyethoxy)aluminium hydride (red-Al) / toluene; tetrahydrofuran / 0 °C

2: O₃ / methanol / -20 °C

3: 1.) ethanolic HCl, 2.) Et₃SiCl, imidazole, 3.) Et₃SiH, TMSOTf

4: CrO₃ / acetone

5: 1.) n-BuLi / 1.) THF, -70 deg C

With 1H-imidazole; chromium(VI) oxide; hydrogenchloride; triethylsilane; n-butyllithium; triethylsilyl chloride; trimethylsilyl trifluoromethanesulfonate; ozone; sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; methanol; acetone; toluene;
DOI:10.1021/jm00054a016