(S)-3-(2-(5-fluoro-1H-indol-1-yl)acetamido)-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid

Base Information

Chemical Name:(S)-3-(2-(5-fluoro-1H-indol-1-yl)acetamido)-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid
CAS No.:1351767-54-8
Molecular Formula:C₂₁H₁₅F₅N₂O₅
Molecular Weight:470.353
Hs Code.:

Synonyms:(S)-3-(2-(5-fluoro-1H-indol-1-yl)acetamido)-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid

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Chemical Property of (S)-3-(2-(5-fluoro-1H-indol-1-yl)acetamido)-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid

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Technology Process of (S)-3-(2-(5-fluoro-1H-indol-1-yl)acetamido)-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid

There total 8 articles about (S)-3-(2-(5-fluoro-1H-indol-1-yl)acetamido)-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 1351767-62-8
C₂₅H₂₃F₅N₂O₅

: 1351767-54-8
(S)-3-(2-(5-fluoro-1H-indol-1-yl)acetamido)-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 0 ℃;

Reference yield:

: 796071-90-4
2-(5-fluoro-1H-indol-1-yl)acetic acid

: 1351767-54-8
(S)-3-(2-(5-fluoro-1H-indol-1-yl)acetamido)-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0 - 20 °C

2: Dess-Martin periodane / dichloromethane / 1.67 h / 0 °C

3: trifluoroacetic acid / dichloromethane / 0 °C

With benzotriazol-1-ol; Dess-Martin periodane; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 254751-10-5
(3S,4RS)-3-amino-5-(2',3',5',6'-tetrafluorophenoxy)-4-hydroxypentanoic acid tert-butyl ester

: 1351767-54-8
(S)-3-(2-(5-fluoro-1H-indol-1-yl)acetamido)-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0 - 20 °C

2: Dess-Martin periodane / dichloromethane / 1.67 h / 0 °C

3: trifluoroacetic acid / dichloromethane / 0 °C

With benzotriazol-1-ol; Dess-Martin periodane; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;