Technology Process of N-{4-[3-(2-chlorophenyl)-4-(1H-imidazol-2-yl)-1H-pyrazol-1-yl]pyridin-2-yl}acetamide
There total 5 articles about N-{4-[3-(2-chlorophenyl)-4-(1H-imidazol-2-yl)-1H-pyrazol-1-yl]pyridin-2-yl}acetamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene;
In
1,4-dioxane; ethyl acetate;
at 135 ℃;
for 2h;
Sealed tube;
Microwave irradiation;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: acetic acid / 1 h / 20 °C
2: trichlorophosphate / 0.5 h / 20 °C
3: glyoxal trimer dihydrate; acetic acid / methanol / 24 h / 20 °C
4: tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane; ethyl acetate / 2 h / 135 °C / Sealed tube; Microwave irradiation
With
tris-(dibenzylideneacetone)dipalladium(0); glyoxal trimer dihydrate; caesium carbonate; acetic acid; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trichlorophosphate;
In
1,4-dioxane; methanol; acetic acid; ethyl acetate;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: glyoxal trimer dihydrate; acetic acid / methanol / 24 h / 20 °C
2: tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane; ethyl acetate / 2 h / 135 °C / Sealed tube; Microwave irradiation
With
tris-(dibenzylideneacetone)dipalladium(0); glyoxal trimer dihydrate; caesium carbonate; acetic acid; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene;
In
1,4-dioxane; methanol; ethyl acetate;
