N-{4-[3-(2-chlorophenyl)-4-(1H-imidazol-2-yl)-1H-pyrazol-1-yl]pyridin-2-yl}acetamide

Base Information

Chemical Name:N-{4-[3-(2-chlorophenyl)-4-(1H-imidazol-2-yl)-1H-pyrazol-1-yl]pyridin-2-yl}acetamide
CAS No.:1445888-69-6
Molecular Formula:C₁₉H₁₅ClN₆O
Molecular Weight:378.821
Hs Code.:

Synonyms:N-{4-[3-(2-chlorophenyl)-4-(1H-imidazol-2-yl)-1H-pyrazol-1-yl]pyridin-2-yl}acetamide

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Chemical Property of N-{4-[3-(2-chlorophenyl)-4-(1H-imidazol-2-yl)-1H-pyrazol-1-yl]pyridin-2-yl}acetamide

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Technology Process of N-{4-[3-(2-chlorophenyl)-4-(1H-imidazol-2-yl)-1H-pyrazol-1-yl]pyridin-2-yl}acetamide

There total 5 articles about N-{4-[3-(2-chlorophenyl)-4-(1H-imidazol-2-yl)-1H-pyrazol-1-yl]pyridin-2-yl}acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 60-35-5
acetamide

: 1445890-36-7
2-chloro-4-[3-(2-chlorophenyl)-4-(1H-imidazol-2-yl)-1H-pyrazol-1-yl]pyridine

: 1445888-69-6
N-{4-[3-(2-chlorophenyl)-4-(1H-imidazol-2-yl)-1H-pyrazol-1-yl]pyridin-2-yl}acetamide

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; ethyl acetate; at 135 ℃; for 2h; Sealed tube; Microwave irradiation;

Reference yield:

: 700811-29-6
(2-chloropyridin-4-yl)hydrazine

: 1445888-69-6
N-{4-[3-(2-chlorophenyl)-4-(1H-imidazol-2-yl)-1H-pyrazol-1-yl]pyridin-2-yl}acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: acetic acid / 1 h / 20 °C

2: trichlorophosphate / 0.5 h / 20 °C

3: glyoxal trimer dihydrate; acetic acid / methanol / 24 h / 20 °C

4: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane; ethyl acetate / 2 h / 135 °C / Sealed tube; Microwave irradiation

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; glyoxal trimer dihydrate; caesium carbonate; acetic acid; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trichlorophosphate; In 1,4-dioxane; methanol; acetic acid; ethyl acetate;

Reference yield:

: 1445890-23-2
3-(2-chlorophenyl)-1-(2-chloropyridin-4-yl)-1H-pyrazole-4-carbaldehyde

: 1445888-69-6
N-{4-[3-(2-chlorophenyl)-4-(1H-imidazol-2-yl)-1H-pyrazol-1-yl]pyridin-2-yl}acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: glyoxal trimer dihydrate; acetic acid / methanol / 24 h / 20 °C

2: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane; ethyl acetate / 2 h / 135 °C / Sealed tube; Microwave irradiation

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; glyoxal trimer dihydrate; caesium carbonate; acetic acid; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; methanol; ethyl acetate;