Technology Process of (4R)-4-benzyl-3-[(2S)-2-benzyloxymethyl-3-(2,4-dimethylphenyl)propionyl]-2-oxazolidinone
There total 5 articles about (4R)-4-benzyl-3-[(2S)-2-benzyloxymethyl-3-(2,4-dimethylphenyl)propionyl]-2-oxazolidinone which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(4R)-4-benzyl-3-[3-(2,4-dimethylphenyl)propionyl]-2-oxazolidinone;
With
titanium tetrachloride; N-ethyl-N,N-diisopropylamine;
In
dichloromethane;
at 0 ℃;
Benzyloxymethyl chloride;
In
dichloromethane;
at 0 - 20 ℃;
DOI:10.3390/90600449
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: H2 / Pd/C / methanol
2.1: aq. NaOH / Heating
3.1: SOCl2 / dimethylformamide / Heating
4.1: n-BuLi; 1,10-phenanthroline / tetrahydrofuran; hexane / -78 °C
5.1: TiCl4; diisopropylethylamine / CH2Cl2 / 0 °C
5.2: 70 percent / CH2Cl2 / 0 - 20 °C
With
sodium hydroxide; n-butyllithium; thionyl chloride; 1,10-Phenanthroline; hydrogen; titanium tetrachloride; N-ethyl-N,N-diisopropylamine;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.3390/90600449
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: SOCl2 / dimethylformamide / Heating
2.1: n-BuLi; 1,10-phenanthroline / tetrahydrofuran; hexane / -78 °C
3.1: TiCl4; diisopropylethylamine / CH2Cl2 / 0 °C
3.2: 70 percent / CH2Cl2 / 0 - 20 °C
With
n-butyllithium; thionyl chloride; 1,10-Phenanthroline; titanium tetrachloride; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.3390/90600449
