7396-44-3Relevant articles and documents
Ir-Catalyzed Remote Functionalization by the Combination of Deconjugative Chain-Walking and C-H Activation Using a Transient Directing Group
Tang, King Hung Nigel,Uchida, Kanako,Nishihara, Kazuki,Ito, Mamoru,Shibata, Takanori
supporting information, p. 1313 - 1317 (2022/02/23)
An Ir-catalyzed reaction of N-benzylideneanilines with functionalized alkenes such as α,β-unsaturated esters gave ortho-substituted benzaldehyde derivatives with a functional group at the remote position after acidic treatment. The present transformation
Synthesis of orthogonally protected (2S)-2-amino-adipic acid (α-AAA) and (2S,4 R)-2-amino-4-hydroxyadipic acid (Ahad)
Yadav, Saroj,Taylor, Carol M.
, p. 5401 - 5409 (2013/07/26)
(2S,4R)-2-Amino-4-hydroxyadipic acid (Ahad) building block 45 was synthesized in 11 steps and 6.5% overall yield from commercially available materials. Key steps in stereocontrol were an asymmetric conjugate addition employing a proline-based catalyst and a syn-selective intramolecular-conjugate addition of an oxygen nucleophile to an α,β-unsaturated ester. To enable incorporation of α-amino-adipic acid (α-AAA) and Ahad into peptides, a truly orthogonal protecting group scheme was developed, encompassing an allyloxycarbonyl (Alloc) carbamate for Nα, a tert-butyl ester for the δ-COOH, an acetol ester for the α-COOH, and a tert- butyldimethylsilyl ether for the γ-hydroxy group of Ahad.
METHOD AND DEVICE
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Page/Page column 17-18, (2008/06/13)
A method of providing suspended cells (10) for carrying out biological assays, comprising the steps of: a) providing a frozen cell suspension, b) bringing the frozen cell suspension into direct contact with an excess volume of thawing buffer (12), and c) incubating the solution of step b) at room temperature in order to thaw the cell suspension.