(E)-2-hydroxy-4-[(3-trifluoromethyl)-3H-diazirin-3-yl]phenyl-2-methylacrylic acid

Base Information

• Chemical Name: (E)-2-hydroxy-4-[(3-trifluoromethyl)-3H-diazirin-3-yl]phenyl-2-methylacrylic acid
• CAS No.: 1422264-01-4
• Molecular Formula: C₁₂H₉F₃N₂O₃
• Molecular Weight: 286.21
• Mol file: 1422264-01-4.mol

Synonyms:(E)-2-hydroxy-4-[(3-trifluoromethyl)-3H-diazirin-3-yl]phenyl-2-methylacrylic acid

Chemical Property of (E)-2-hydroxy-4-[(3-trifluoromethyl)-3H-diazirin-3-yl]phenyl-2-methylacrylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-2-hydroxy-4-[(3-trifluoromethyl)-3H-diazirin-3-yl]phenyl-2-methylacrylic acid

There total 2 articles about (E)-2-hydroxy-4-[(3-trifluoromethyl)-3H-diazirin-3-yl]phenyl-2-methylacrylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

(E)-ethyl 3-[2-hydroxy-4-(3-trifluoromethyl-3H-diazirin-3-yl)phenyl]-2-methylacrylate (1422263-99-7) → (E)-2-hydroxy-4-[(3-trifluoromethyl)-3H-diazirin-3-yl]phenyl-2-methylacrylic acid (1422264-01-4)

Guidance literature:

With water; sodium hydroxide; In methanol; at 0 - 20 ℃; for 2h;

DOI:10.1039/c3cc38594a

Reference yield:

2-hydroxy-4-[3-(trifluoromethyl)-3H-diazirin-3-yl] benzaldehyde (308085-25-8) → (E)-2-hydroxy-4-[(3-trifluoromethyl)-3H-diazirin-3-yl]phenyl-2-methylacrylic acid (1422264-01-4)

Guidance literature:

Multi-step reaction with 2 steps

1: benzene / 20 °C / Inert atmosphere

2: sodium hydroxide; water / methanol / 2 h / 0 - 20 °C

With water; sodium hydroxide; In methanol; benzene;

DOI:10.1039/c3cc38594a

Reference yield: 84.0%

(9H-fluoren-9-yl)methanethiol (957753-00-3) + (E)-2-hydroxy-4-[(3-trifluoromethyl)-3H-diazirin-3-yl]phenyl-2-methylacrylic acid (1422264-01-4) → C26H19F3N2O2S

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; at 20 ℃; for 8h; Inert atmosphere;

DOI:10.1002/asia.201900859

upstream raw materials:

2-hydroxy-4-[3-(trifluoromethyl)-3H-diazirin-3-yl] benzaldehyde

(E)-ethyl 3-[2-hydroxy-4-(3-trifluoromethyl-3H-diazirin-3-yl)phenyl]-2-methylacrylate