2-Hydroxy-4-[3-(trifluoromethyl)-3H-diazirin-3-yl]benzaldehyde

Base Information

• Chemical Name: 2-Hydroxy-4-[3-(trifluoromethyl)-3H-diazirin-3-yl]benzaldehyde
• CAS No.: 308085-25-8
• Molecular Formula: C9H5F3N2O2
• Molecular Weight: 230.146
• Hs Code.: 2933998090
• Mol file: 308085-25-8.mol

Synonyms:2-hydroxy-4-[3-(trifluoromethyl)-3H-diazirin-3-yl]benzaldehyde;2-hydroxy-4-(3-trifluoromethyl-3H-diazirin-3-yl)benzaldehyde;2-Hydroxy-4-(3-trifluoromethyl-3H-diazirin-3-yl)-benzaldehyde;2-hydroxy-4-[3-(trifluoromethyl)-3H-diazirine-3-yl]benzaldehyde;2-hydroxy-4-(3-(trifluoromethyl)-3H-diazirin-3-yl)benzaldehyde;

Chemical Property of 2-Hydroxy-4-[3-(trifluoromethyl)-3H-diazirin-3-yl]benzaldehyde

Chemical Property:

• Melting Point: 44 °C
• Boiling Point: 277.5±50.0℃ (760 Torr)
• Flash Point: 121.6±30.1℃
• PSA: 62.02000
• Density: 1.59±0.1 g/cm3 (20 oC 760 Torr)
• LogP: 1.25680

Purity/Quality:

4-(3-(Trifluoromethyl)-3H-diazirin-3-yl)-2-hydroxybenzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Hydroxy-4-[3-(trifluoromethyl)-3H-diazirin-3-yl]benzaldehyde

There total 1 articles about 2-Hydroxy-4-[3-(trifluoromethyl)-3H-diazirin-3-yl]benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2-methoxy-4-<3-trifluoromethyl-3H-diazirin-3-yl>benzaldehyde (205485-25-2) → 2-hydroxy-4-[3-(trifluoromethyl)-3H-diazirin-3-yl] benzaldehyde (308085-25-8)

Guidance literature:

With boron tribromide; In dichloromethane; at -20 - 0 ℃; for 1h;

Reference yield: 100.0%

C27H31O2P + 2-hydroxy-4-[3-(trifluoromethyl)-3H-diazirin-3-yl] benzaldehyde (308085-25-8) → C18H21F3N2O3

Guidance literature:

In dichloromethane; at 20 ℃; for 5h; Inert atmosphere;

DOI:10.1002/anie.201408580

Reference yield: 96.0%

2-hydroxy-4-[3-(trifluoromethyl)-3H-diazirin-3-yl] benzaldehyde (308085-25-8) + 2-[2-(2-tert-butoxycarbonylaminoethoxy)ethoxy]ethyl bromide → 2-[2-[2-(2-tert-butoxycarbonylaminoethoxy)ethoxy]ethoxy]-4-[3-(trifluoromethyl)-3H-diazirin-3-yl] benzaldehyde (299931-13-8)

Guidance literature:

With potassium carbonate; tetra-(n-butyl)ammonium iodide; In DMF (N,N-dimethyl-formamide); at 60 ℃; for 14h;

upstream raw materials:

2-methoxy-4-<3-trifluoromethyl-3H-diazirin-3-yl>benzaldehyde

Downstream raw materials:

2-[2-[2-(2-tert-butoxycarbonylaminoethoxy)ethoxy]ethoxy]-4-[3-(trifluoromethyl)-3H-diazirin-3-yl] benzaldehyde

18-[2-formyl-5-(3-trifluoromethyl-3H-diazirin-3-yl)-phenoxy]-octadec-9-enoic acid methyl ester

C₂₀H₂₅N₂O₆F₃

2-{[8-(tetrahydropyran-2-yloxy)-octyloxy]-4-(3-trifluoromethyl-3H-diazirin-3-yl)}-benzaldehyde