tert-butyl 4-(5-(2-(2-(2-methanesulfonylethoxy)ethoxy)ethoxy)benzofuran-2-yl)phenyl-N-methylcarbamate

Base Information

Chemical Name:tert-butyl 4-(5-(2-(2-(2-methanesulfonylethoxy)ethoxy)ethoxy)benzofuran-2-yl)phenyl-N-methylcarbamate
CAS No.:1287783-13-4
Molecular Formula:C₂₇H₃₅NO₉S
Molecular Weight:549.642
Hs Code.:

Synonyms:tert-butyl 4-(5-(2-(2-(2-methanesulfonylethoxy)ethoxy)ethoxy)benzofuran-2-yl)phenyl-N-methylcarbamate

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Chemical Property of tert-butyl 4-(5-(2-(2-(2-methanesulfonylethoxy)ethoxy)ethoxy)benzofuran-2-yl)phenyl-N-methylcarbamate

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Technology Process of tert-butyl 4-(5-(2-(2-(2-methanesulfonylethoxy)ethoxy)ethoxy)benzofuran-2-yl)phenyl-N-methylcarbamate

There total 10 articles about tert-butyl 4-(5-(2-(2-(2-methanesulfonylethoxy)ethoxy)ethoxy)benzofuran-2-yl)phenyl-N-methylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.8%

: 1287783-12-3
tert-butyl 4-(5-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)benzofuran-2-yl)phenyl-N-methylcarbamate

: 124-63-0
methanesulfonyl chloride

: 1287783-13-4
tert-butyl 4-(5-(2-(2-(2-methanesulfonylethoxy)ethoxy)ethoxy)benzofuran-2-yl)phenyl-N-methylcarbamate

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1021/jm200057u

Reference yield:

: 672-13-9
2-hydroxy-5-methoxybenzaldehyde

: 1287783-13-4
tert-butyl 4-(5-(2-(2-(2-methanesulfonylethoxy)ethoxy)ethoxy)benzofuran-2-yl)phenyl-N-methylcarbamate

Guidance literature:: Multi-step reaction with 9 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / Reflux

2.1: tin(ll) chloride / ethanol / 2 h / Reflux

3.1: sodium methylate / methanol / 1 h / Reflux

3.2: 2 h / Reflux

4.1: boron tribromide / dichloromethane / 1 h / 20 °C / Cooling with ice

4.2: Cooling with ice

5.1: potassium carbonate / N,N-dimethyl-formamide / 18 h / 100 °C

6.1: 1H-imidazole / dichloromethane / 4 h / 20 °C

7.1: tetrahydrofuran / Reflux

8.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C

9.1: triethylamine / dichloromethane / 2 h / 20 °C

With 1H-imidazole; tetrabutyl ammonium fluoride; sodium methylate; boron tribromide; potassium carbonate; triethylamine; tin(ll) chloride; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm200057u

Reference yield:

: 888704-00-5
[4-(5-methoxy-benzofuran-2-yl)-phenyl]-methyl-amine

: 1287783-13-4
tert-butyl 4-(5-(2-(2-(2-methanesulfonylethoxy)ethoxy)ethoxy)benzofuran-2-yl)phenyl-N-methylcarbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: boron tribromide / dichloromethane / 1 h / 20 °C / Cooling with ice

1.2: Cooling with ice

2.1: potassium carbonate / N,N-dimethyl-formamide / 18 h / 100 °C

3.1: 1H-imidazole / dichloromethane / 4 h / 20 °C

4.1: tetrahydrofuran / Reflux

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C

6.1: triethylamine / dichloromethane / 2 h / 20 °C

With 1H-imidazole; tetrabutyl ammonium fluoride; boron tribromide; potassium carbonate; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm200057u