cis 1,3-Dibenzyl-4-(2'-diphenylphosphinoyl-1'-hydroxyethyl)-5-t-butyldimethylsilyloxymethylimidazolidin-2-one

Base Information

Chemical Name:cis 1,3-Dibenzyl-4-(2'-diphenylphosphinoyl-1'-hydroxyethyl)-5-t-butyldimethylsilyloxymethylimidazolidin-2-one
CAS No.:133709-65-6
Molecular Formula:C₃₈H₄₇N₂O₄PSi
Molecular Weight:654.861
Hs Code.:

Synonyms:cis 1,3-Dibenzyl-4-(2'-diphenylphosphinoyl-1'-hydroxyethyl)-5-t-butyldimethylsilyloxymethylimidazolidin-2-one

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Chemical Property of cis 1,3-Dibenzyl-4-(2'-diphenylphosphinoyl-1'-hydroxyethyl)-5-t-butyldimethylsilyloxymethylimidazolidin-2-one

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Technology Process of cis 1,3-Dibenzyl-4-(2'-diphenylphosphinoyl-1'-hydroxyethyl)-5-t-butyldimethylsilyloxymethylimidazolidin-2-one

There total 4 articles about cis 1,3-Dibenzyl-4-(2'-diphenylphosphinoyl-1'-hydroxyethyl)-5-t-butyldimethylsilyloxymethylimidazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 133709-62-3,133775-09-4
cis 1,3-Dibenzyl-4-(1'-hydroxy-2'-diphenylphosphinoylethyl)-5-hydroxymethylimidazolidin-2-one

: 18162-48-6
tert-butyldimethylsilyl chloride

: 133709-65-6
cis 1,3-Dibenzyl-4-(2'-diphenylphosphinoyl-1'-hydroxyethyl)-5-t-butyldimethylsilyloxymethylimidazolidin-2-one

Guidance literature:: With triethylamine; dmap; In dichloromethane; Ambient temperature;

Reference yield:

: 1779-49-3
Methyltriphenylphosphonium bromide

: 133709-65-6
cis 1,3-Dibenzyl-4-(2'-diphenylphosphinoyl-1'-hydroxyethyl)-5-t-butyldimethylsilyloxymethylimidazolidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / 15percent aq. NaOH / 1 h / Heating

2: 1) n-BuLi, o-phenanthroline / 1) THF, -78 deg C, 30 min, 2) -30 deg C, 2.5 h

3: 84 percent / NaBH₄ / methanol / 18 h / Ambient temperature

4: 94 percent / NEt₃ / 4-dimethylaminopyridine / CH₂Cl₂ / Ambient temperature

With sodium hydroxide; sodium tetrahydroborate; n-butyllithium; 1,10-Phenanthroline; triethylamine; dmap; In methanol; dichloromethane;

Reference yield:

: 133732-50-0
cis 1,3-Dibenzyl-4-diphenylphosphinoylmethyl-4-hydroxy-2,3,3a,4,6,6a-hexahydro-furo<3,4-d>imidazol-2-one

: 133709-65-6
cis 1,3-Dibenzyl-4-(2'-diphenylphosphinoyl-1'-hydroxyethyl)-5-t-butyldimethylsilyloxymethylimidazolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 84 percent / NaBH₄ / methanol / 18 h / Ambient temperature

2: 94 percent / NEt₃ / 4-dimethylaminopyridine / CH₂Cl₂ / Ambient temperature

With sodium tetrahydroborate; triethylamine; dmap; In methanol; dichloromethane;