2-[(2-tert-butoxycarbonylamino-ethyl)-(9H-fluoren-9-ylmethoxycarbonyl)-amino]-6-(2-chloro-benzyloxycarbonylamino)-hexanoic acid allyl ester

Base Information

• Chemical Name: 2-[(2-tert-butoxycarbonylamino-ethyl)-(9H-fluoren-9-ylmethoxycarbonyl)-amino]-6-(2-chloro-benzyloxycarbonylamino)-hexanoic acid allyl ester
• CAS No.: 548490-52-4
• Molecular Formula: C₃₉H₄₆ClN₃O₈
• Molecular Weight: 720.263

Synonyms:2-[(2-tert-butoxycarbonylamino-ethyl)-(9H-fluoren-9-ylmethoxycarbonyl)-amino]-6-(2-chloro-benzyloxycarbonylamino)-hexanoic acid allyl ester

Chemical Property of 2-[(2-tert-butoxycarbonylamino-ethyl)-(9H-fluoren-9-ylmethoxycarbonyl)-amino]-6-(2-chloro-benzyloxycarbonylamino)-hexanoic acid allyl ester

Chemical Property:

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Technology Process of 2-[(2-tert-butoxycarbonylamino-ethyl)-(9H-fluoren-9-ylmethoxycarbonyl)-amino]-6-(2-chloro-benzyloxycarbonylamino)-hexanoic acid allyl ester

There total 1 articles about 2-[(2-tert-butoxycarbonylamino-ethyl)-(9H-fluoren-9-ylmethoxycarbonyl)-amino]-6-(2-chloro-benzyloxycarbonylamino)-hexanoic acid allyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

(fluorenylmethoxy)carbonyl chloride (28920-43-6) + (R)-2-(2-tert-Butoxycarbonylamino-ethylamino)-6-(2-chloro-benzyloxycarbonylamino)-hexanoic acid allyl ester (183127-28-8) → 2-[(2-tert-butoxycarbonylamino-ethyl)-(9H-fluoren-9-ylmethoxycarbonyl)-amino]-6-(2-chloro-benzyloxycarbonylamino)-hexanoic acid allyl ester (548490-52-4)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 2h;

DOI:10.1002/ejoc.200390148

Reference yield: 80.0%

2-[(2-tert-butoxycarbonylamino-ethyl)-(9H-fluoren-9-ylmethoxycarbonyl)-amino]-6-(2-chloro-benzyloxycarbonylamino)-hexanoic acid allyl ester (548490-52-4) → 2-[(2-tert-butoxycarbonylamino-ethyl)-(9H-fluoren-9-ylmethoxycarbonyl)-amino]-6-(2-chloro-benzyloxycarbonylamino)-hexanoic acid (548490-53-5)

Guidance literature:

With morpholine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran;

DOI:10.1002/ejoc.200390148

upstream raw materials:

(fluorenylmethoxy)carbonyl chloride

(R)-2-(2-tert-Butoxycarbonylamino-ethylamino)-6-(2-chloro-benzyloxycarbonylamino)-hexanoic acid allyl ester

Downstream raw materials:

2-[(2-tert-butoxycarbonylamino-ethyl)-(9H-fluoren-9-ylmethoxycarbonyl)-amino]-6-(2-chloro-benzyloxycarbonylamino)-hexanoic acid

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