3’-O-(tertbutyldimethylsilyl)-5’-O-(4,4’-dimethoxytrityl)-N2-phenoxyacetyl-2’-deoxyguanosine

Base Information

• Chemical Name: 3’-O-(tertbutyldimethylsilyl)-5’-O-(4,4’-dimethoxytrityl)-N2-phenoxyacetyl-2’-deoxyguanosine
• CAS No.: 642462-83-7
• Molecular Formula: C₄₅H₅₁N₅O₈Si
• Molecular Weight: 818.014
• Mol file: 642462-83-7.mol

Synonyms:3’-O-(tertbutyldimethylsilyl)-5’-O-(4,4’-dimethoxytrityl)-N2-phenoxyacetyl-2’-deoxyguanosine

Chemical Property of 3’-O-(tertbutyldimethylsilyl)-5’-O-(4,4’-dimethoxytrityl)-N2-phenoxyacetyl-2’-deoxyguanosine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3’-O-(tertbutyldimethylsilyl)-5’-O-(4,4’-dimethoxytrityl)-N2-phenoxyacetyl-2’-deoxyguanosine

There total 1 articles about 3’-O-(tertbutyldimethylsilyl)-5’-O-(4,4’-dimethoxytrityl)-N2-phenoxyacetyl-2’-deoxyguanosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.2%

5’-O-dimethoxytrityl-N2-phenoxyacetyl-2’-deoxyguanosine (110522-81-1) + tert-butyldimethylsilyl chloride (18162-48-6) → 3’-O-(tertbutyldimethylsilyl)-5’-O-(4,4’-dimethoxytrityl)-N2-phenoxyacetyl-2’-deoxyguanosine (642462-83-7)

Guidance literature:

With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

DOI:10.1039/c0ob00093k

Reference yield: 71.1%

3'-O-alloxycarbonyl-5'-O-dimethoxytrityl-N2-phenoxyacetyl-O6-(7-hydroxyheptyl)-2'-deoxyguanosine (918947-06-5) + 3’-O-(tertbutyldimethylsilyl)-5’-O-(4,4’-dimethoxytrityl)-N2-phenoxyacetyl-2’-deoxyguanosine (642462-83-7) → 1-{O6-[3'-O-alloxycarbonyl-5'-O-dimethoxytrityl-N2-phenoxyacetyl-2'-deoxyguanidyl]}-4-{O6-[3'-O-tertbutyldimethylsilyl-5'-O-dimethoxytrityl-N2-phenoxyacetyl-2'-deoxyguanidyl]}-heptane (1254514-29-8)

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine; In 1,4-dioxane; for 0.5h;

DOI:10.1039/c0ob00093k

Reference yield: 70.0%

3’-O-(tertbutyldimethylsilyl)-5’-O-(4,4’-dimethoxytrityl)-N2-phenoxyacetyl-2’-deoxyguanosine (642462-83-7) + 3'-O-(tert-butyldimethylsilyl)-5'-O-(4,4'-dimethoxytrityl)-O4-(hydroxyheptyl)thymidine (1396763-85-1) → 1-{O4-[3′-O-(t-butyldimethylsilyl)-5′-O-(4,4′-dimethoxytrityl)thymidinyl]}-7-{O6-[3′-O-(t-butyldimethylsilyl)-5′-O-(4,4′-dimethoxytrityl)-N2-phenoxyacetyl-2'-deoxyguanosinyl]}heptane (1421765-84-5)

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine; In 1,4-dioxane; at 20 ℃; for 22h;

DOI:10.1021/bc300553u

upstream raw materials:

5’-O-dimethoxytrityl-N²-phenoxyacetyl-2’-deoxyguanosine

tert-butyldimethylsilyl chloride

Downstream raw materials:

1-{O₆-[3'-O-alloxycarbonyl-5'-O-dimethoxytrityl-N₂-phenoxyacetyl-2'-deoxyguanidyl]}-4-{O₆-[3'-O-tertbutyldimethylsilyl-5'-O-dimethoxytrityl-N₂-phenoxyacetyl-2'-deoxyguanidyl]}-heptane

1-{O₆-[3'-O-alloxycarbonyl-5'-O-dimethoxytrityl-N₂-phenoxyacetyl-2'-deoxyguanidyl]}-4-{O₆-[3'-O-tertbutyldimethylsilyl-5'-O-dimethoxytrityl-N₂-phenoxyacetyl-2'-deoxyguanidyl]}-butane

1-{O⁴-[3′-O-(t-butyldimethylsilyl)-5'-O-(4,4′-dimethoxytrityl)thymidinyl]}-4-{O⁶-[3'-O-(t-butyldimethylsilyl)-5'-O-(4,4'-dimethoxytrityl)-N²-phenoxyacetyl-2'-deoxyguanosinyl]}butane

1-{O⁴-[3′-O-(t-butyldimethylsilyl)-5′-O-(4,4′-dimethoxytrityl)thymidinyl]}-7-{O6-[3′-O-(t-butyldimethylsilyl)-5′-O-(4,4′-dimethoxytrityl)-N²-phenoxyacetyl-2'-deoxyguanosinyl]}heptane