110522-81-1

Upstream product

• 961-07-9 2'-Deoxyguanosine 
• 110522-76-4 Phenoxy-acetic acid (2R,3S,5R)-5-[6-oxo-2-(2-phenoxy-acetylamino)-1,6-dihydro-purin-9-yl]-2-(2-phenoxy-acetoxymethyl)-tetrahydro-furan-3-yl ester 
• 109464-23-5 N-(9-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-benzamide 
• 81144-43-6 5'-O-(p,p'-dimethoxytrityl)-2'-deoxyguanosine 
• 14316-61-1 phenoxyacetic anhydride 

Downstream Products

• 118533-24-7 Succinic acid mono-{(2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-[6-oxo-2-(2-phenoxy-acetylamino)-1,6-dihydro-purin-9-yl]-tetrahydro-furan-3-yl} ester 
• 642462-83-7 3’-O-(tertbutyldimethylsilyl)-5’-O-(4,4’-dimethoxytrityl)-N2-phenoxyacetyl-2’-deoxyguanosine 
• 1323344-95-1 3’-O-(tert-butyldimethylsilyl)-N²-phenoxyacetyl-2’-deoxyguanosine 

Relevant academic research and scientific papers

Synthesis of oligodeoxyribonucleoside methylphosphonates containing 2- aminopurine

Oligodeoxyribonucleoside methylphosphonates containing multiple 2- aminopurine bases were synthesized by solid-phase phosphonamidite chemistry for investigating their triple helix formation with natural DNA or other duplex targets and for cellular uptake studies of the methylphosphonate oligomers. The base-labile phenoxyacetyl group was used as the N2-amino protecting group for 2-aminopurine, allowing the final deprotection of the oligomers to be performed under the standard ehtylenediamine condition.

FACILE REMOVAL OF NEW BASE PROTECTING GROUPS USEFUL IN OLIGONUCLEOTIDE SYNTHESIS

New base protecting groups are proposed in place of benzoyl and isobutyryl groups.They are phenoxy acetyl for adenine and guanine and isobutyryl for cytosine.They are cleaved in aqueous ammonia in a shorter time at lower temperature.These easily removable groups are useful in the synthesis of modified oligonucleotides, containing fragile bases.