methyl 2-(5-tert-butoxy-5-oxopentyl)-4-oxo-3-p-tolyl3,4-dihydroquinazoline-7-carboxylate

Base Information

Chemical Name:methyl 2-(5-tert-butoxy-5-oxopentyl)-4-oxo-3-p-tolyl3,4-dihydroquinazoline-7-carboxylate
CAS No.:1373278-36-4
Molecular Formula:C₂₆H₃₀N₂O₅
Molecular Weight:450.535
Hs Code.:

Synonyms:methyl 2-(5-tert-butoxy-5-oxopentyl)-4-oxo-3-p-tolyl3,4-dihydroquinazoline-7-carboxylate

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Chemical Property of methyl 2-(5-tert-butoxy-5-oxopentyl)-4-oxo-3-p-tolyl3,4-dihydroquinazoline-7-carboxylate

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Technology Process of methyl 2-(5-tert-butoxy-5-oxopentyl)-4-oxo-3-p-tolyl3,4-dihydroquinazoline-7-carboxylate

There total 8 articles about methyl 2-(5-tert-butoxy-5-oxopentyl)-4-oxo-3-p-tolyl3,4-dihydroquinazoline-7-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: methyl 2-(5-tert-butoxy-5-oxopentyl)-4-oxo-2,4-dihydro-1H-benzo[d][1,3]oxazine-7-carboxylate

: 106-49-0,12221-03-3
p-toluidine

: 1373278-36-4
methyl 2-(5-tert-butoxy-5-oxopentyl)-4-oxo-3-p-tolyl3,4-dihydroquinazoline-7-carboxylate

Guidance literature:: With acetic acid; at 100 ℃;

Reference yield:

: 55737-66-1
2-nitro-4-methoxycarbonylbenzoic acid

: 1373278-36-4
methyl 2-(5-tert-butoxy-5-oxopentyl)-4-oxo-3-p-tolyl3,4-dihydroquinazoline-7-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen / 5%-palladium/activated carbon / water; methanol / 16 h / 2585.81 Torr

2: triethylamine / tetrahydrofuran / 16 h / 20 °C

3: acetic anhydride / 16 h / Reflux

4: acetic acid / 100 °C

With hydrogen; acetic anhydride; acetic acid; triethylamine; 5%-palladium/activated carbon; In tetrahydrofuran; methanol; water;

Reference yield:

: 627-91-8
adipic acid monomethyl ester

: 1373278-36-4
methyl 2-(5-tert-butoxy-5-oxopentyl)-4-oxo-3-p-tolyl3,4-dihydroquinazoline-7-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: boron trifluoride diethyl etherate / dichloromethane / 0 - 20 °C

2: water; lithium hydroxide / tetrahydrofuran; methanol / 16 h / 20 °C

3: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 20 °C

4: triethylamine / tetrahydrofuran / 16 h / 20 °C

5: acetic anhydride / 16 h / Reflux

6: acetic acid / 100 °C

With oxalyl dichloride; boron trifluoride diethyl etherate; water; acetic anhydride; acetic acid; triethylamine; lithium hydroxide; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; dichloromethane;