(-)-(1R,2R)-2-N,N-dimethylamino-1-ethoxycarbonylmethoxy-1,2-diphenylethane

Base Information

Chemical Name:(-)-(1R,2R)-2-N,N-dimethylamino-1-ethoxycarbonylmethoxy-1,2-diphenylethane
CAS No.:249622-09-1
Molecular Formula:C₂₀H₂₅NO₃
Molecular Weight:327.423
Hs Code.:

Synonyms:(-)-(1R,2R)-2-N,N-dimethylamino-1-ethoxycarbonylmethoxy-1,2-diphenylethane

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Chemical Property of (-)-(1R,2R)-2-N,N-dimethylamino-1-ethoxycarbonylmethoxy-1,2-diphenylethane

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Technology Process of (-)-(1R,2R)-2-N,N-dimethylamino-1-ethoxycarbonylmethoxy-1,2-diphenylethane

There total 1 articles about (-)-(1R,2R)-2-N,N-dimethylamino-1-ethoxycarbonylmethoxy-1,2-diphenylethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 105-36-2
ethyl bromoacetate

: 249622-08-0
(1R,2R)-2-(dimethylamino)-1,2-diphenylethanol

: 249622-09-1
(-)-(1R,2R)-2-N,N-dimethylamino-1-ethoxycarbonylmethoxy-1,2-diphenylethane

Guidance literature:: (1R,2R)-2-(dimethylamino)-1,2-diphenylethanol; With n-butyllithium; In N,N-dimethyl-formamide; at -60 ℃; for 1h;

ethyl bromoacetate; In N,N-dimethyl-formamide; at -30 ℃; for 48h;
DOI:10.1016/S0040-4020(99)00644-4

Reference yield: 72.0%

: 75-31-0
isopropylamine

: 249622-09-1
(-)-(1R,2R)-2-N,N-dimethylamino-1-ethoxycarbonylmethoxy-1,2-diphenylethane

: 249622-10-4
(-)-(1R,2R)-2-N,N-dimethylamino-1-isopropylaminocarbonylmethoxy-1,2-diphenylethane

Guidance literature:: With sodium methylate; In toluene; at 55 ℃; for 24h;
DOI:10.1016/S0040-4020(99)00644-4

Reference yield:

: 249622-09-1
(-)-(1R,2R)-2-N,N-dimethylamino-1-ethoxycarbonylmethoxy-1,2-diphenylethane

: (-)-(1R,2R)-2-N,N-dimethylamino-1-[2-(isopropylamino)ethoxy]-1,2-diphenylethane

Guidance literature:: Multi-step reaction with 2 steps

1: 72 percent / NaOCH₃ / toluene / 24 h / 55 °C

2: 73 percent / LiAlH₄ / tetrahydrofuran / 4 h / Heating

With lithium aluminium tetrahydride; sodium methylate; In tetrahydrofuran; toluene; 1: Substitution / 2: Reduction;
DOI:10.1016/S0040-4020(99)00644-4