1,3-bis-(2-(1-(4-(4-(pyrrolidin-1-yl)butanamido)phenyl)-1H-1,2,3-triazol-4-yl)phenyl)urea

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Chemical Name:1,3-bis-(2-(1-(4-(4-(pyrrolidin-1-yl)butanamido)phenyl)-1H-1,2,3-triazol-4-yl)phenyl)urea
CAS No.:1070978-51-6
Molecular Formula:C₄₅H₅₀N₁₂O₃
Molecular Weight:806.971
Hs Code.:

Synonyms:1,3-bis-(2-(1-(4-(4-(pyrrolidin-1-yl)butanamido)phenyl)-1H-1,2,3-triazol-4-yl)phenyl)urea

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Chemical Property of 1,3-bis-(2-(1-(4-(4-(pyrrolidin-1-yl)butanamido)phenyl)-1H-1,2,3-triazol-4-yl)phenyl)urea

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Technology Process of 1,3-bis-(2-(1-(4-(4-(pyrrolidin-1-yl)butanamido)phenyl)-1H-1,2,3-triazol-4-yl)phenyl)urea

There total 5 articles about 1,3-bis-(2-(1-(4-(4-(pyrrolidin-1-yl)butanamido)phenyl)-1H-1,2,3-triazol-4-yl)phenyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 1070979-25-7
1,3-bis(2-ethynylphenyl)urea

: 1070978-80-1
N-(4-azidophenyl)-4-(pyrrolidin-1-yl)butanamide

: 1070978-51-6
1,3-bis-(2-(1-(4-(4-(pyrrolidin-1-yl)butanamido)phenyl)-1H-1,2,3-triazol-4-yl)phenyl)urea

Guidance literature:: With copper(ll) sulfate pentahydrate; sodium 2-(1,2-dihydroxyethyl)-4-hydroxy-5-oxo-2,5-dihydro-furan-3-olate; In water; tert-butyl alcohol; at 130 ℃; for 0.5h; Microwave irradiation;
DOI:10.1039/b814576h

Reference yield:

: 875924-09-7
N-(4'-nitrophenyl)-4-(pyrrolidin-1-yl)butanamide

: 1070978-51-6
1,3-bis-(2-(1-(4-(4-(pyrrolidin-1-yl)butanamido)phenyl)-1H-1,2,3-triazol-4-yl)phenyl)urea

Guidance literature:: Multi-step reaction with 3 steps

1: ammonium formate / palladium on activated charcoal / methanol / 20 °C

2: hydrogenchloride; tert.-butylnitrite / tetrahydrofuran; water / 1 h / 0 °C

3: copper(II) sulfate; sodium L-ascorbate / water; tert-butyl alcohol / 0.5 h / 130 °C / Microwave irradiation

With hydrogenchloride; tert.-butylnitrite; ammonium formate; copper(II) sulfate; sodium L-ascorbate; palladium on activated charcoal; In tetrahydrofuran; methanol; water; tert-butyl alcohol;

Reference yield:

: 100-01-6,104810-17-5
4-nitro-aniline

: 1070978-51-6
1,3-bis-(2-(1-(4-(4-(pyrrolidin-1-yl)butanamido)phenyl)-1H-1,2,3-triazol-4-yl)phenyl)urea

Guidance literature:: Multi-step reaction with 5 steps

1: 20 - 50 °C

2: 30 °C

3: ammonium formate / palladium on activated charcoal / methanol / 20 °C

4: hydrogenchloride; tert.-butylnitrite / tetrahydrofuran; water / 1 h / 0 °C

5: copper(II) sulfate; sodium L-ascorbate / water; tert-butyl alcohol / 0.5 h / 130 °C / Microwave irradiation

With hydrogenchloride; tert.-butylnitrite; ammonium formate; copper(II) sulfate; sodium L-ascorbate; palladium on activated charcoal; In tetrahydrofuran; methanol; water; tert-butyl alcohol;