{4-[2-(4-{2-[4-(2-{4-[2-(4-Acetylamino-phenyl)-acetoxy]-phenyl}-acetoxy)-phenyl]-acetoxy}-phenyl)-acetoxy]-phenyl}-acetic acid

Base Information

• Chemical Name: {4-[2-(4-{2-[4-(2-{4-[2-(4-Acetylamino-phenyl)-acetoxy]-phenyl}-acetoxy)-phenyl]-acetoxy}-phenyl)-acetoxy]-phenyl}-acetic acid
• CAS No.: 335200-33-4
• Molecular Formula: C₄₂H₃₅NO₁₁
• Molecular Weight: 729.74
• Mol file: 335200-33-4.mol

Synonyms:{4-[2-(4-{2-[4-(2-{4-[2-(4-Acetylamino-phenyl)-acetoxy]-phenyl}-acetoxy)-phenyl]-acetoxy}-phenyl)-acetoxy]-phenyl}-acetic acid

Chemical Property of {4-[2-(4-{2-[4-(2-{4-[2-(4-Acetylamino-phenyl)-acetoxy]-phenyl}-acetoxy)-phenyl]-acetoxy}-phenyl)-acetoxy]-phenyl}-acetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of {4-[2-(4-{2-[4-(2-{4-[2-(4-Acetylamino-phenyl)-acetoxy]-phenyl}-acetoxy)-phenyl]-acetoxy}-phenyl)-acetoxy]-phenyl}-acetic acid

There total 9 articles about {4-[2-(4-{2-[4-(2-{4-[2-(4-Acetylamino-phenyl)-acetoxy]-phenyl}-acetoxy)-phenyl]-acetoxy}-phenyl)-acetoxy]-phenyl}-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

[4-(2-{4-[2-(4-Acetylamino-phenyl)-acetoxy]-phenyl}-acetoxy)-phenyl]-acetic acid 4-(4-benzyloxycarbonylmethyl-phenoxycarbonylmethyl)-phenyl ester (335200-43-6) → {4-[2-(4-{2-[4-(2-{4-[2-(4-Acetylamino-phenyl)-acetoxy]-phenyl}-acetoxy)-phenyl]-acetoxy}-phenyl)-acetoxy]-phenyl}-acetic acid (335200-33-4)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; dichloromethane; ethyl acetate; for 4h;

DOI:10.1039/b008065i

Reference yield:

benzyl p-hydroxyphenylacetate (27727-37-3) → {4-[2-(4-{2-[4-(2-{4-[2-(4-Acetylamino-phenyl)-acetoxy]-phenyl}-acetoxy)-phenyl]-acetoxy}-phenyl)-acetoxy]-phenyl}-acetic acid (335200-33-4)

Guidance literature:

Multi-step reaction with 8 steps

1: 90 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; 1-hydroxybenzotriazole hydrate; N,N-diisopropylethylamine / tetrahydrofuran / 4 h / 20 °C

2: 95 percent / H₂ / Pd/C / methanol / 2 h

3: 93 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; 1-hydroxybenzotriazole hydrate; N,N-diisopropylethylamine / tetrahydrofuran / 3 h

4: 92 percent / H₂ / Pd/C / methanol; CH₂Cl₂ / 2 h

5: 51 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; 1-hydroxybenzotriazole hydrate; N,N-diisopropylethylamine / dimethylformamide; tetrahydrofuran / 18 h

6: 81 percent / H₂ / Pd/C / methanol; CH₂Cl₂ / 2 h

7: 16 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; 1-hydroxybenzotriazole hydrate; N,N-diisopropylethylamine / dimethylformamide; tetrahydrofuran / 4 h

8: 95 percent / H₂ / Pd/C / methanol; CH₂Cl₂; ethyl acetate / 4 h

With hydrogen; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1039/b008065i

Reference yield:

4-hydroxyphenylacetate (156-38-7) → {4-[2-(4-{2-[4-(2-{4-[2-(4-Acetylamino-phenyl)-acetoxy]-phenyl}-acetoxy)-phenyl]-acetoxy}-phenyl)-acetoxy]-phenyl}-acetic acid (335200-33-4)

Guidance literature:

Multi-step reaction with 9 steps

1: 75 percent / 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 16 °C / Heating

2: 90 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; 1-hydroxybenzotriazole hydrate; N,N-diisopropylethylamine / tetrahydrofuran / 4 h / 20 °C

3: 95 percent / H₂ / Pd/C / methanol / 2 h

4: 93 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; 1-hydroxybenzotriazole hydrate; N,N-diisopropylethylamine / tetrahydrofuran / 3 h

5: 92 percent / H₂ / Pd/C / methanol; CH₂Cl₂ / 2 h

6: 51 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; 1-hydroxybenzotriazole hydrate; N,N-diisopropylethylamine / dimethylformamide; tetrahydrofuran / 18 h

7: 81 percent / H₂ / Pd/C / methanol; CH₂Cl₂ / 2 h

8: 16 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; 1-hydroxybenzotriazole hydrate; N,N-diisopropylethylamine / dimethylformamide; tetrahydrofuran / 4 h

9: 95 percent / H₂ / Pd/C / methanol; CH₂Cl₂; ethyl acetate / 4 h

With hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1039/b008065i

upstream raw materials:

[4-(2-{4-[2-(4-Acetylamino-phenyl)-acetoxy]-phenyl}-acetoxy)-phenyl]-acetic acid 4-(4-benzyloxycarbonylmethyl-phenoxycarbonylmethyl)-phenyl ester

(4-acetylamino-phenyl)-acetic acid 4-benzyloxycarbonylmethyl-phenyl ester

{4-[2-(4-Acetylamino-phenyl)-acetoxy]-phenyl}-acetic acid 4-benzyloxycarbonylmethyl-phenyl ester

(4-{2-[4-(2-{4-[2-(4-Acetylamino-phenyl)-acetoxy]-phenyl}-acetoxy)-phenyl]-acetoxy}-phenyl)-acetic acid

Downstream raw materials:

(4-{2-[4-(2-{4-[2-(4-Acetylamino-phenyl)-acetoxy]-phenyl}-acetoxy)-phenyl]-acetoxy}-phenyl)-acetic acid 4-[4-(4-benzyloxycarbonylmethyl-phenoxycarbonylmethyl)-phenoxycarbonylmethyl]-phenyl ester

4-hydroxyphenylacetate

4-acetamidophenylacetic acid

{4-[2-(4-Acetylamino-phenyl)-acetoxy]-phenyl}-acetic acid