naphthalen-1-yl-2-iodobenzoate

Base Information

• Chemical Name: naphthalen-1-yl-2-iodobenzoate
• CAS No.: 205178-58-1
• Molecular Formula: C₁₇H₁₁IO₂
• Molecular Weight: 374.178
• Mol file: 205178-58-1.mol

Synonyms:naphthalen-1-yl-2-iodobenzoate

Chemical Property of naphthalen-1-yl-2-iodobenzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of naphthalen-1-yl-2-iodobenzoate

There total 2 articles about naphthalen-1-yl-2-iodobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

α-naphthol (90-15-3) + 2-Iodobenzoyl chloride (609-67-6) → naphthalen-1-yl-2-iodobenzoate (205178-58-1)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 0 - 25 ℃; for 3h; Inert atmosphere; Schlenk technique;

DOI:10.1039/c6dt01022a

Reference yield:

2-Iodobenzoic acid (88-67-5) → naphthalen-1-yl-2-iodobenzoate (205178-58-1)

Guidance literature:

Multi-step reaction with 2 steps

1: oxalyl chloride; DMF / tetrahydrofuran / 1 h / 20 °C

2: pyridine

With pyridine; oxalyl dichloride; N,N-dimethyl-formamide; In tetrahydrofuran; 1: Chlorination / 2: Esterification;

DOI:10.1248/cpb.48.861

Reference yield: 79.0%

naphthalen-1-yl-2-iodobenzoate (205178-58-1) → triphenylene (217-59-4) + 6H-benzo[d]naphtho[1,2-b]pyran-6-one (55377-35-0)

Guidance literature:

With C₁₈H₁₉Cl₂N₂PPd; sodium acetate; In N,N-dimethyl-formamide; at 160 ℃; for 0.333333h; Inert atmosphere; Schlenk technique;

DOI:10.1039/c6dt01022a

upstream raw materials:

α-naphthol

2-Iodobenzoyl chloride

2-Iodobenzoic acid

Downstream raw materials:

(1-hydroxynaphthalen-2-yl)(2-iodophenyl)methanone

(2-iodo-phenyl)-(1-methoxy-naphthalen-2-yl)-methanone

triphenylene

6H-benzo[d]naphtho[1,2-b]pyran-6-one

Refernces

• 1、 Harayama, Takashi,Yasuda, Hirotake,Akiyama, Toshihiko,Takeuchi, Yasuo,Abe, Hitoshi. "Synthesis of arnottin I through a palladium-mediated aryl-aryl coupling reaction". . p. 861 - 864. Retrieved 2007/10/03.