4,4-Dimethyl-2-(5-formyl-2-isopropyl-3,4-dimethoxyphenyl)-2-oxazoline

Base Information

• Chemical Name: 4,4-Dimethyl-2-(5-formyl-2-isopropyl-3,4-dimethoxyphenyl)-2-oxazoline
• CAS No.: 194998-10-2
• Molecular Formula: C₁₈H₂₇NO₄
• Molecular Weight: 321.417
• Mol file: 194998-10-2.mol

Synonyms:4,4-Dimethyl-2-(5-formyl-2-isopropyl-3,4-dimethoxyphenyl)-2-oxazoline

Chemical Property of 4,4-Dimethyl-2-(5-formyl-2-isopropyl-3,4-dimethoxyphenyl)-2-oxazoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4,4-Dimethyl-2-(5-formyl-2-isopropyl-3,4-dimethoxyphenyl)-2-oxazoline

There total 5 articles about 4,4-Dimethyl-2-(5-formyl-2-isopropyl-3,4-dimethoxyphenyl)-2-oxazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

ethyl vinyl ether (109-92-2,25104-37-4) + N,N-dimethyl-formamide (68-12-2,33513-42-7) + 4,4-dimethyl-2-(2-isopropyl-3,4-dimethoxyphenyl)-2-oxazoline (99425-55-5) → 4,4-Dimethyl-2-(5-formyl-2-isopropyl-3,4-dimethoxyphenyl)-2-oxazoline (194998-10-2)

Guidance literature:

Multistep reaction;

DOI:10.1016/S0040-4020(98)00501-8

Reference yield:

4,4-dimethyl-2-(2-isopropyl-3,4-dimethoxyphenyl)-2-oxazoline (99425-55-5) → 4,4-Dimethyl-2-(5-formyl-2-isopropyl-3,4-dimethoxyphenyl)-2-oxazoline (194998-10-2)

Guidance literature:

Multi-step reaction with 3 steps

1: EtOCH=CHLi / hexamethylphosphoric acid triamide

2: LiAlH₄

3: NaH

With lithium aluminium tetrahydride; sodium hydride; α-ethoxyvinyllithium; In N,N,N,N,N,N-hexamethylphosphoric triamide;

DOI:10.1039/a703043f

Reference yield:

2,3,4-Trimethoxy-benzoic acid (573-11-5) → 4,4-Dimethyl-2-(5-formyl-2-isopropyl-3,4-dimethoxyphenyl)-2-oxazoline (194998-10-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: (COCl)2; DMF / CH₂Cl₂ / 4 h / 20 °C

1.2: 96 percent / thionyl chloride / CH₂Cl₂ / 12 h / 20 °C

2.1: 96 percent / 4 h / reflux

3.1: 72 percent

With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; 1.1: Chlorination / 1.2: Cyclization / 2.1: Substitution;

DOI:10.1016/S0040-4020(98)00501-8

upstream raw materials:

methyl iodide

ethyl vinyl ether

N,N-dimethyl-formamide

4,4-dimethyl-2-(2-isopropyl-3,4-dimethoxyphenyl)-2-oxazoline

Downstream raw materials:

2-Isopropyl-3,4-dimethoxy-5-methoxymethylbenzaldehyde