5-O-benzoyl-2-deoxy-2,2-difluoro-3-O-(p-phenylbenzoyl)-α-D-ribofuranosyl bromide

Base Information

• Chemical Name: 5-O-benzoyl-2-deoxy-2,2-difluoro-3-O-(p-phenylbenzoyl)-α-D-ribofuranosyl bromide
• CAS No.: 874633-78-0
• Molecular Formula: C₂₅H₁₉BrF₂O₅
• Molecular Weight: 517.324

Synonyms:5-O-benzoyl-2-deoxy-2,2-difluoro-3-O-(p-phenylbenzoyl)-α-D-ribofuranosyl bromide

Chemical Property of 5-O-benzoyl-2-deoxy-2,2-difluoro-3-O-(p-phenylbenzoyl)-α-D-ribofuranosyl bromide

Chemical Property:

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Technology Process of 5-O-benzoyl-2-deoxy-2,2-difluoro-3-O-(p-phenylbenzoyl)-α-D-ribofuranosyl bromide

There total 2 articles about 5-O-benzoyl-2-deoxy-2,2-difluoro-3-O-(p-phenylbenzoyl)-α-D-ribofuranosyl bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

diphenyl 5-O-benzoyl-2-deoxy-2,2-difluoro-3-O-(p-phenylbenzoyl)-β-D-ribofuranosyl phosphate (874633-76-8) → 5-O-benzoyl-2-deoxy-2,2-difluoro-3-O-(p-phenylbenzoyl)-α-D-ribofuranosyl bromide (874633-78-0)

Guidance literature:

With hydrogen bromide; In acetic acid; at 20 ℃; for 6h;

Reference yield: 82.0%

diphenyl 5-O-benzoyl-2-deoxy-2,2-difluoro-3-O-(p-phenylbenzoyl)-β-D-ribofuranosyl phosphate (874633-76-8) → 5-O-benzoyl-2-deoxy-2,2-difluoro-3-O-(p-phenylbenzoyl)-α-D-ribofuranosyl bromide (874633-78-0) + 1-β-bromo-2-deoxy-2,2-difluoro-D-riboniranosyl-3-benzoyl-5-(4-phenyl)benzoate

Guidance literature:

With hydrogen bromide; acetic acid; at 20 ℃; for 6h; Product distribution / selectivity;

Reference yield:

5-O-benzoyl-2-deoxy-2,2-difluoro-3-O-(p-phenylbenzoyl)-α-D-ribofuranosyl bromide (874633-78-0) + N,O-bis-(trimethylsilyl)-acetamide (10416-59-8) + N4-acetyl-O-trimethylsilylcytosine (54230-57-8) → 1-(2'-deoxy-2',2'-difluoro-5-benzoyl-3-(4-phenyl)benzoyl-β-D-arabinofuranosyl)-4-acetylaminopyrimidine-2-one + C31H25F2N3O7 + trimethylsilyl bromide (2857-97-8)

Guidance literature:

In n-heptane; at 135 - 140 ℃; for 8h;

upstream raw materials:

diphenyl 5-O-benzoyl-2-deoxy-2,2-difluoro-3-O-(p-phenylbenzoyl)-β-D-ribofuranosyl phosphate

Downstream raw materials:

trimethylsilyl bromide

1-(2'-deoxy-2',2'-difluoro-5-benzoyl-3-(4-phenyl)benzoyl-β-D-arabinofuranosyl)-4-aminopyrimidine-2-one

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