(-)-(4S,5S)-2-((Diethylphosphono)-methyl)-4-(methoxymethyl)-5-phenyl-2-oxazoline

Base Information

Chemical Name:(-)-(4S,5S)-2-((Diethylphosphono)-methyl)-4-(methoxymethyl)-5-phenyl-2-oxazoline
CAS No.:78249-21-5
Molecular Formula:C₁₆H₂₄NO₅P
Molecular Weight:341.344
Hs Code.:

Synonyms:(-)-(4S,5S)-2-((Diethylphosphono)-methyl)-4-(methoxymethyl)-5-phenyl-2-oxazoline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (-)-(4S,5S)-2-((Diethylphosphono)-methyl)-4-(methoxymethyl)-5-phenyl-2-oxazoline

Chemical Property:

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Technology Process of (-)-(4S,5S)-2-((Diethylphosphono)-methyl)-4-(methoxymethyl)-5-phenyl-2-oxazoline

There total 1 articles about (-)-(4S,5S)-2-((Diethylphosphono)-methyl)-4-(methoxymethyl)-5-phenyl-2-oxazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 52075-14-6
(4S,5S)-(-)-4,5-dihydro-4-methoxymethyl-2-methyl-5-phenyloxazole

: 814-49-3
diethyl chlorophosphate

: 78249-21-5
(-)-(4S,5S)-2-((Diethylphosphono)-methyl)-4-(methoxymethyl)-5-phenyl-2-oxazoline

Guidance literature:: With n-butyllithium; diisopropylamine; Yield given. Multistep reaction; 1.) THF, hexane, -78 deg C, 2h, 2.) 25 deg C, 27h;
DOI:10.1021/jo00332a023

Reference yield: 89.0%

: 2100-17-6
4-pentenal

: 78249-21-5
(-)-(4S,5S)-2-((Diethylphosphono)-methyl)-4-(methoxymethyl)-5-phenyl-2-oxazoline

: 99285-40-2
(4S,5S)-(+)-2-<1-(E-1,5-hexadienyl)>-4-methoxymethyl-5-phenyl-2-oxazoline

Guidance literature:: With potassium tert-butylate; In tetrahydrofuran; at -78 ℃;

Reference yield:

: 78249-21-5
(-)-(4S,5S)-2-((Diethylphosphono)-methyl)-4-(methoxymethyl)-5-phenyl-2-oxazoline

: 78249-24-8
(4S,5S)-2-<(2S,3S,4R,5R)-7-(Benzyloxy)-3,5-(benzylidenedioxy)-4-methoxy-2-butylheptyl>-4-(methoxymethyl)-5-phenyl-2-oxazoline

Guidance literature:: Multi-step reaction with 2 steps

1: NaH / 1.) 1,2-dimethoxyethane, room temp., 70 min, 2.) dimethoxyethane, 0 deg C, 4h

2: 78 percent / tetrahydrofuran; hexane / 2 h / -78 °C

With sodium hydride; In tetrahydrofuran; hexane;
DOI:10.1021/jo00332a023