Cyclohexanecarboxylic acid, 3-amino-, methyl ester, cis- (9CI)

Base Information

• Chemical Name: Cyclohexanecarboxylic acid, 3-amino-, methyl ester, cis- (9CI)
• CAS No.: 202120-10-3
• Molecular Formula: C₈H₁₅NO₂
• Molecular Weight: 157.213
• Mol file: 202120-10-3.mol

Synonyms:Cyclohexanecarboxylicacid, 3-amino-, methyl ester, cis- (9CI)

Chemical Property of Cyclohexanecarboxylic acid, 3-amino-, methyl ester, cis- (9CI)

Chemical Property:

• Boiling Point: 215.7±33.0 °C(Predicted)
• PKA: 10.03±0.70(Predicted)
• Density: 1.036±0.06 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Cyclohexanecarboxylic acid, 3-amino-, methyl ester, cis- (9CI)

There total 10 articles about Cyclohexanecarboxylic acid, 3-amino-, methyl ester, cis- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

methanol (67-56-1) + racemic trans-3-((tert-butoxycarbonyl)amino)cyclohexane-1-carboxylic acid (218772-92-0,222530-33-8) → C8H15NO2 (202120-10-3,761386-09-8)

Guidance literature:

With thionyl chloride; for 2h;

Reference yield: 97.3%

methanol (67-56-1) + (+/-)-cis-3-aminocyclohexanecarboxylic acid (16636-51-4,25912-50-9,34583-99-8,38541-66-1,57043-02-4,81131-39-7,81131-40-0,41235-88-5,933445-51-3,933445-54-6) → (rac)-(1R,3S)-methyl 3-aminocyclchexanecarboxylate (202120-10-3,761386-09-8)

Guidance literature:

With hydrogenchloride; at 20 ℃; for 12h;

Reference yield: 90.9%

methanol (67-56-1) + cis-3-aminocyclohexanecarboxylic acid (41235-88-5,933445-51-3,933445-54-6) → cis-methyl 3-aminocyclohexanecarboxylate (202120-10-3,761386-09-8)

Guidance literature:

methanol; cis-3-aminocyclohexanecarboxylic acid; With thionyl chloride; at 0 ℃; for 12h; Reflux;

With sodium hydrogencarbonate; In water; ethyl acetate;

upstream raw materials:

methanol

3-aminocyclohexanecarboxylic acid

methyl 3-[(tert-butoxycarbonyl)amino]cyclohexanecarboxylate

trans-3-aminocyclohexane-1-carboxylic acid

Downstream raw materials:

3-({5-[2-(3,4-dichloro-phenyl)-vinyl]-1H-pyrazol-3-ylmethyl}-amino)-cyclohexanecarboxylic acid methyl ester

4-(tert-butyl-diphenyl-silanyloxy)-3-[(3-methoxycarbonyl-cyclohexylamino)-methyl]-indazole-1-carboxylic acid tert-butyl ester