1-(5-benzoylhexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)-2-(4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl)ethane-1,2-dione

Base Information

Chemical Name:1-(5-benzoylhexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)-2-(4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl)ethane-1,2-dione
CAS No.:1426310-90-8
Molecular Formula:C₂₆H₂₅N₇O₄
Molecular Weight:499.529
Hs Code.:

Synonyms:1-(5-benzoylhexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)-2-(4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl)ethane-1,2-dione

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Chemical Property of 1-(5-benzoylhexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)-2-(4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl)ethane-1,2-dione

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Technology Process of 1-(5-benzoylhexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)-2-(4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl)ethane-1,2-dione

There total 8 articles about 1-(5-benzoylhexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)-2-(4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl)ethane-1,2-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67443-38-3
5-bromo-2-chloro-3-nitropyridine

: 1426310-90-8
1-(5-benzoylhexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)-2-(4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl)ethane-1,2-dione

Guidance literature:: Multi-step reaction with 6 steps

1: tetrahydrofuran / 3 h / -78 - -40 °C

2: copper(l) iodide / 3 h / 110 °C / Microwave irradiation

3: copper; potassium hydroxide / 170 - 175 °C / Inert atmosphere

4: ethylmagnesium bromide; pyridine / tetrahydrofuran / 1 h / -45 - -10 °C

5: sodium hydroxide; water / methanol / 6 h / 25 °C

6: diethyl (4-oxobenzo[d][1,2,3]triazin-3(4H)-yl)phosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 12 h / 20 °C

With pyridine; copper(l) iodide; diethyl (4-oxobenzo[d][1,2,3]triazin-3(4H)-yl)phosphate; ethylmagnesium bromide; water; copper; N-ethyl-N,N-diisopropylamine; potassium hydroxide; sodium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.3390/molecules23081940

Reference yield:

: 7170-01-6
3-methyl-1H-[1,2,4]triazole

: 5781-53-3
monomethyl oxalyl chloride

: 1426310-90-8
1-(5-benzoylhexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)-2-(4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl)ethane-1,2-dione

Guidance literature:: With hydrogenchloride; triethanolamine; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile; Petroleum ether; trichlorophosphate;

Reference yield:

: 676491-47-7
2-(4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-oxoacetic acid

: 1312664-37-1
(hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)(phenyl)methanone

: 1426310-90-8
1-(5-benzoylhexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)-2-(4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl)ethane-1,2-dione

Guidance literature:: With diethyl (4-oxobenzo[d][1,2,3]triazin-3(4H)-yl)phosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 12h;
DOI:10.3390/molecules23081940