(2S,3S)-2-Amino-1,4-di-O-benzylthreitol

Base Information

Chemical Name:(2S,3S)-2-Amino-1,4-di-O-benzylthreitol
CAS No.:107938-43-2
Molecular Formula:C₁₈H₂₃NO₃
Molecular Weight:301.386
Hs Code.:

Synonyms:(2S,3S)-2-Amino-1,4-di-O-benzylthreitol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,3S)-2-Amino-1,4-di-O-benzylthreitol

Chemical Property:

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Technology Process of (2S,3S)-2-Amino-1,4-di-O-benzylthreitol

There total 11 articles about (2S,3S)-2-Amino-1,4-di-O-benzylthreitol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 81177-24-4
(S,S)-1,4-bis(benzyloxy)-2,3-epoxybutane

: 107938-43-2
(2S,3S)-2-Amino-1,4-di-O-benzylthreitol

Guidance literature:: With ammonia; In methanol; at 100 ℃; for 35h;
DOI:10.1055/s-1986-31788

Reference yield:

: 69010-01-1
(2R*,3S*)-1,4-bis(benzyloxy)butane-2,3-diol

: 107938-43-2
(2S,3S)-2-Amino-1,4-di-O-benzylthreitol

Guidance literature:: Multi-step reaction with 8 steps

1: p-TsOH, molecular sieves 4A / CH₂Cl₂ / Ambient temperature

2: 80 percent / B-phenyl-oxazaborolidine derivative / CH₂Cl₂ / 15 h / -78 °C

3: i-Pr₂NEt

4: LDA / tetrahydrofuran / 0 °C

5: pyridine

6: tetramethylguanidinium azide / acetonitrile

7: HCl / methanol

8: H₂ / Pd black

With pyridine; hydrogenchloride; 4 A molecular sieve; B-phenyl-oxazaborolidine derivative; hydrogen; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; tetramethylguanidinum azide; lithium diisopropyl amide; palladium; In tetrahydrofuran; methanol; dichloromethane; acetonitrile;
DOI:10.1016/S0040-4039(98)00823-5

Reference yield:

: 195374-95-9
(2S,4R,5S)-4,5-Bis-benzyloxymethyl-2-phenylethynyl-[1,3]dioxolane

: 107938-43-2
(2S,3S)-2-Amino-1,4-di-O-benzylthreitol

Guidance literature:: Multi-step reaction with 7 steps

1: 80 percent / B-phenyl-oxazaborolidine derivative / CH₂Cl₂ / 15 h / -78 °C

2: i-Pr₂NEt

3: LDA / tetrahydrofuran / 0 °C

4: pyridine

5: tetramethylguanidinium azide / acetonitrile

6: HCl / methanol

7: H₂ / Pd black

With pyridine; hydrogenchloride; B-phenyl-oxazaborolidine derivative; hydrogen; N-ethyl-N,N-diisopropylamine; tetramethylguanidinum azide; lithium diisopropyl amide; palladium; In tetrahydrofuran; methanol; dichloromethane; acetonitrile;
DOI:10.1016/S0040-4039(98)00823-5