Propargyl-PEG8-amine

Base Information

• Chemical Name: Propargyl-PEG8-amine
• CAS No.: 1196732-52-1
• Molecular Formula: C₁₉H₃₇NO₈
• Molecular Weight: 407.505
• Hs Code.: 2921199990
• Mol file: 1196732-52-1.mol

Synonyms:3,6,9,12,15,18,21,24-octaoxaheptacos-26-yn-1-amine

Chemical Property of Propargyl-PEG8-amine

Chemical Property:

• Solubility.: Soluble in Water, DMSO, DCM, DMF

Purity/Quality:

98%,99%, ^*data from raw suppliers

Propargyl-PEG8-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Description: Propargyl-PEG8-amine is a heterobifunctional reagent consisting of a propargyl group and an amine group. The amine group can form amide bonds with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The propargyl group can form triazole linkage with azides in copper catalyzed Click Chemistry reactions.
• Uses: Propargyl-peg8-amine is used as a reactant in the synthesis of synthetic antibody mimics targeting prostate cancer.

Technology Process of Propargyl-PEG8-amine

There total 7 articles about Propargyl-PEG8-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

C27H39NO10 (1422540-96-2) → 3,6,9,12,15,18,21,24-octaoxaheptacos-26-yn-1-amine (1196732-52-1)

Guidance literature:

With hydrazine; In ethanol; at 60 ℃; for 3h;

DOI:10.1039/c2ob26968f

Reference yield: 91.0%

1-azido-3,6,9,12,15,18,21,24-octaoxaheptacos-26-yne (1196733-06-8) → 3,6,9,12,15,18,21,24-octaoxaheptacos-26-yn-1-amine (1196732-52-1)

Guidance literature:

With water; triphenylphosphine; In tetrahydrofuran; for 12h; Inert atmosphere;

DOI:10.1021/ja906844e

Reference yield:

octaethylene glycol (5117-19-1) → 3,6,9,12,15,18,21,24-octaoxaheptacos-26-yn-1-amine (1196732-52-1)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran / 20 °C

1.2: 16 h / 20 - 60 °C

2.1: triethylamine / dichloromethane / 4 h / 0 - 20 °C

3.1: N,N-dimethyl-formamide / 15 h / 110 °C

4.1: hydrazine / ethanol / 3 h / 60 °C

With sodium hydride; triethylamine; hydrazine; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1039/c2ob26968f

upstream raw materials:

1-azido-3,6,9,12,15,18,21,24-octaoxaheptacos-26-yne

α-(2-azidoethyl)-ω-hydroxyhexa(oxyethylene)

C₂₀H₃₈O₁₁S

C₂₇H₃₉NO₁₀

Downstream raw materials:

N-(2,4-dinitrophenyl)-3,6,9,12,15,18,21,24-octaoxaheptacos-26-yn-1-amine

(S)-2-(3-((S)-1-carboxy-5-(4-(25-(2,4-dinitrophenylamino)-2,5,8,11,14,17,20,23-octaoxapentacosyl)-1H-1,2,3-triazol-1-yl)pentyl)ureido)pentanedioic acid

C₄₆H₆₅N₃O₁₄S₂

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