5117-19-1

Usage

Uses

Used in Pharmaceutical and Bioconjugation Applications:
Octaethylene glycol is used as a bioconjugation agent for attaching biologically active molecules to other molecules or surfaces. Its hydrophilic nature and flexibility make it an ideal candidate for improving the solubility and stability of various pharmaceutical compounds.
Used in Drug Delivery Systems:
Octaethylene glycol is employed as a component in drug delivery systems, where it can enhance the solubility, bioavailability, and controlled release of therapeutic agents. Its hydrophilic properties also help to reduce the immunogenicity and non-specific interactions of drug molecules.
Used in PEG Hydrogels:
Octaethylene glycol is used as a crosslinker in the formation of PEG hydrogels, which are three-dimensional networks of hydrophilic polymers. These hydrogels have applications in tissue engineering, drug delivery, and wound healing due to their biocompatibility, tunable mechanical properties, and ability to encapsulate bioactive molecules.
Used in Surface Functionalization:
Octaethylene glycol is utilized for surface functionalization, where it can be used to modify the properties of various materials, such as improving their biocompatibility, reducing protein adsorption, or enhancing cell adhesion.
Used in Antioxidant, Antimicrobial, and Anti-Cancer Applications:
As part of a leaf extract from Murdannia Bracteata, octaethylene glycol exhibits antioxidant, antimicrobial, and anti-cancer properties. Its presence in the extract contributes to the overall therapeutic effects and potential applications in various medical and health-related fields.
Used in Functional Hydraulic Fluids:
Octaethylene glycol shows potential application as a component in functional hydraulic fluids, where its properties can improve the performance, stability, and lifespan of the fluid in various industrial and mechanical applications.

InChI:InChI=1/C16H34O9/c17-1-3-19-5-7-21-9-11-23-13-15-25-16-14-24-12-10-22-8-6-20-4-2-18/h17-18H,1-16H2

Upstream product

• 111-44-4 3-oxa-1,5-dichloropentane 
• 112-27-6 2,2'-[1,2-ethanediylbis(oxy)]bisethanol 
• 112-60-7 Tetraethylene glycol 
• 105891-51-8 (2-{2-[2-(2-Chloro-ethoxy)-ethoxy]-ethoxy}-ethoxymethyl)-benzene 
• 125274-16-0 1,1,1-triphenyl-2,5,8,11-tetraoxatridecan-13-ol 
• 89346-82-7 2-<2-<2-<2-(benzyloxy)ethoxy>ethoxy>ethoxy>ethyl 4-methylbenzenesulfonate 
• 1144113-16-5 2-(2-{2-[2-(2-{2-[2-(2-trityloxyethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethoxy}ethoxy)ethanol 
• 86259-87-2 1-phenyl-2,5,8,11-tetraoxatridecan-13-ol 
• 37860-51-8 tetraethylene glycol di(p-toluenesulfonate) 
• 2615-15-8 pentaethylene glycol 
• 721918-45-2 {2-[2-(2-{2-[2-(2-isopropoxycarbonylmethoxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-acetic acid isopropyl ester 
• 638-56-2 1,11-dichloro-3,6,9-trioxaundecane 
• 105891-54-1 1,27-diphenyl-2,5,8,11,14,17,20,23,26-nonaoxaheptacosane 
• 144270-98-4 1,1,1,27,27,27-hexaphenyl-2,5,8,11,14,17, 20,23,26-nonaoxaheptacosane 

Downstream Products

• 33089-37-1 24-crown-8 
• 71092-61-0 48-Crown-16 
• 41028-41-5 octaethyleneglycol 3-(3',5'-di-t-butyl-4'-hydroxyphenyl)propionate 
• 1092554-87-4 4,7,10,13,16,19,22,25,28-nonaoxahentriaconta-1,30-diyne 
• 1355481-26-3 C₈₀H₁₂₈O₂₄ 
• 177987-04-1 1,23-dibromo-3,6,9,12,15,18,21-heptaoxatricosane 
• 133604-58-7 hexadecylethylene glycol monomethylether 
• 6812-36-8 hexadecaethylene glycol 
• 105891-54-1 1,27-diphenyl-2,5,8,11,14,17,20,23,26-nonaoxaheptacosane 

Relevant academic research and scientific papers

Supramolecular compound nano-carrier as well as preparation method and application thereof

The invention discloses a supramolecular compound nano-carrier as well as a preparation method and application thereof, and relates to the technical field of polymer chemistry and biological detection engineering. According to the supramolecular compound nano-carrier disclosed by the invention, a two-dimensional nanosheet supramolecular structure system generated by self-assembly is driven by an anion induction effect, and a supramolecular compound nano-carrier is of a single-layer nanosheet supramolecular structure constructed by a highly-oriented one-dimensional nanorod. A hydrophobic perylene group part is used as a skeleton part for constructing the highly-oriented one-dimensional nanorod, and the charge density of a single-layer nanosheet can be regulated and controlled. The surface of the water-soluble multivalent hydrophilic part can be loaded with DNAzyme deoxyribozyme for specific detection of heavy metal ions through electrostatic interaction, and the water-soluble multivalent supramolecular compound nano sensor is constructed. Based on a fluorescence change mechanism caused by specific cutting of heavy metal ions, The fluorescence detection of the heavy metal ions in food and biological tissues is realized, and the detection effect of the heavy metal ions is greatly enhanced.

Optimization of IEDDA bioorthogonal system: Efficient process to improve trans-cyclooctene/tetrazine interaction

The antibody pretargeting approach for radioimmunotherapy (RIT) using inverse electron demand Diels-Alder cycloaddition (IEDDA) constitutes an emerging theranostic approach for solid cancers. However, IEDDA pretargeting has not reached clinical trial. The major limitation of the IEDDA strategy depends largely on trans-cyclooctene (TCO) stability. Indeed, TCO may isomerize into the more stable but unreactive cis-cyclooctene (CCO), leading to a drastic decrease of IEDDA efficiency. We have thus developed both efficient and reproducible synthetic pathways and analytical follow up for (PEGylated) TCO derivatives, providing high TCO isomeric purity for antibody modification. We have set up an original process to limit the isomerization of TCO to CCO before the mAbs’ functionalization to allow high TCO/tetrazine cycloaddition.

PROTAC compound for targeted degradation of IDO1, and preparation method and application thereof

The invention provides a PROTAC compound represented by formula I and used for targeted degradation of IDO1, and a pharmaceutically acceptable salt, a hydrate or a solvate thereof. In the formula I, Xrepresents -CH2 or -C = O, Y represents -CH2 or -C= O, and n is a natural number from 2 to 9. The PROTAC compound for targeted degradation of the IDO1 has efficient activity of targeted degradation of the IDO1 protein.

Highly efficient synthesis of monodisperse poly(ethylene glycols) and derivatives through macrocyclization of oligo(ethylene glycols)

A macrocyclic sulfate (MCS)-based approach to monodisperse poly(ethylene glycols) (M-PEGs) and their monofunctionalized derivatives has been developed. Macrocyclization of oligo(ethylene glycols) (OEGs) provides MCS (up to a 62-membered macrocycle) as versatile precursors for a range of monofunctionalized M-PEGs. Through iterative nucleophilic ring-opening reactions of MCS without performing group protection and activation, a series of M-PEGs, including the unprecedented 64-mer (2850Da), can be readily prepared. Synthetic simplicity coupled with versatility of this new strategy may pave the way for broader applications of M-PEGs. Macrocycles make synthesis easier: Convenient macrocyclization of the OEGs provides versatile macrocyclic sulfates. These compounds are cornerstones for both monofunctionalization of OEGs and highly efficient synthesis of monodisperse PEGs and derivatives, including an unprecedented 64-mer.

Convenient multigram synthesis of monodisperse oligo(ethylene glycols): Effective reaction monitoring by infrared spectroscopy using an attenuated total reflection fibre optic probe

A convenient approach for the synthesis of monodisperse oligo(ethylene glycols) up to 12 units is described. A novel cleavage protocol replacing laborious hydrogenolysis is introduced to achieve a fast, inexpensive and widely applicable procedure. In addition to the synthetic part, Fourier transform infrared (FTIR) spectroscopy using a fibre optic attenuated total reflection (ATR) sensor was applied to monitor the formation of sensitive key intermediates, resulting in optimized reaction times. By applying this in-line technique, the possibility of real-time analysis under inert conditions was impressively demonstrated.

Synthesis of oligo(ethylene glycol) toward 44-mer

A synthetic method for oligo(ethylene glycol) toward 44-mer (FW = 1956.35) is described. Reiteration of Williamson's ether synthesis and hydrogenation to remove protecting benzyl group affords desired oligo(ethylene glycol) toward 44-mer in moderate yields. The advantages in this method are use of commercially easily available materials as starting materials and procedures avoiding difficulty in purification of the products as much as possible.

An expedient synthesis of monodispersed oligo(ethylene glycols)

A convenient approach to the synthesis of oligo(ethylene glycols) under phase transfer conditions is described. Oligo(ethylene glycols) (x = 7-12) are obtained in excellent yields and high purity via modular, bi-directional elongation of readily available ethylene glycol bis-tosylates.

HIV protease inhibitors having polyether substituents

[From equivalent EP0487270A2] Polyether derivatives of the form, A-G-B-B-J ψ wherein G is a dipeptide isostere substituted with a polyether, B an amino acid or analog thereof, and J a small terminal group are described. These compounds are useful in the inhibition of DIV protease, the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.ψ