5117-19-1

Basic information

• Product Name: OCTAETHYLENE GLYCOL
• Synonyms: HO-PEG(8)-OH;OCTAETHYLENE GLYCOL;PED-DIOL (N=8);3,6,9,12,15,18,21-Heptaoxatricosane-21,23-diol;Octoethyleneglycol;3,6,9,12,15,18,21-heptaoxatricosane-1,23-diol;POLYETHYLENEGLYCOL8;HO-8-OH
• CAS NO: 5117-19-1
• Molecular Formula: C₁₆H₃₄O₉
• Molecular Weight: 370.44
• EINECS: 225-856-4
• Product Categories: Ethylene Glycols;Ethylene Glycols & Monofunctional Ethylene Glycols;Chemical Biology;Chemical Synthesis;High Oligomer Purity PEG;PEGylation
• Mol File: 5117-19-1.mol
• Article Data: 14

Chemical Properties

• Melting Point: 22 °C
• Boiling Point: 471.5 °C at 760 mmHg
• Flash Point: 239 °C
• Appearance: /
• Density: 1.13
• Vapor Pressure: 7.16E-11mmHg at 25°C
• Refractive Index: 1.4640-1.4680
• Storage Temp.: -20°C
• PKA: 14.06±0.10(Predicted)
• CAS DataBase Reference: OCTAETHYLENE GLYCOL(CAS DataBase Reference)
• NIST Chemistry Reference: OCTAETHYLENE GLYCOL(5117-19-1)
• EPA Substance Registry System: OCTAETHYLENE GLYCOL(5117-19-1)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 5117-19-1(Hazardous Substances Data)

Usage

Description

Octanethylene glycol is a polymer consisting of ethylene glycol monomers and two terminal hydroxyl groups. The PEG chain increases the water solubility of a compound in aqueous media. Increasing the number of ethylene glycol units within the entire chain improves the solubility properties of the PEG linker.

Uses

Different sources of media describe the Uses of 5117-19-1 differently. You can refer to the following data:
1. Octaethylene Glycol is part of a leaf extract (Murdannia Bracteata) which was shown to exhibit antioxidant, antimicrobial and anti-cancer properties.Octaethylene Glycol also shows potential application as functional hydraulic fluids.
2. Applications may include: bioconjugation, drug delivery, PEG hydrogel, crosslinker, and surface functionalization

InChI:InChI=1/C16H34O9/c17-1-3-19-5-7-21-9-11-23-13-15-25-16-14-24-12-10-22-8-6-20-4-2-18/h17-18H,1-16H2

Upstream product

• 89346-82-7 2-<2-<2-<2-(benzyloxy)ethoxy>ethoxy>ethoxy>ethyl 4-methylbenzenesulfonate 
• 125274-16-0 1,1,1-triphenyl-2,5,8,11-tetraoxatridecan-13-ol 
• 105891-51-8 (2-{2-[2-(2-Chloro-ethoxy)-ethoxy]-ethoxy}-ethoxymethyl)-benzene 
• 86259-87-2 1-phenyl-2,5,8,11-tetraoxatridecan-13-ol 
• 37860-51-8 tetraethylene glycol di(p-toluenesulfonate) 
• 721918-43-0 (2-{2-[2-(2-isopropoxycarbonylmethoxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-acetic acid isopropyl ester 
• 2615-15-8 pentaethylene glycol 
• 721918-45-2 {2-[2-(2-{2-[2-(2-isopropoxycarbonylmethoxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-acetic acid isopropyl ester 
• 111-44-4 3-oxa-1,5-dichloropentane 
• 638-56-2 1,11-dichloro-3,6,9-trioxaundecane 
• 105891-54-1 1,27-diphenyl-2,5,8,11,14,17,20,23,26-nonaoxaheptacosane 
• 144270-98-4 1,1,1,27,27,27-hexaphenyl-2,5,8,11,14,17, 20,23,26-nonaoxaheptacosane 
• 88099-82-5 2-methyl-26-crown-9 
• 107-21-1 ethylene glycol 

Downstream Products

• 41028-41-5 octaethyleneglycol 3-(3',5'-di-t-butyl-4'-hydroxyphenyl)propionate 
• 1454333-65-3 23-hydroxy-3,6,9,12,15,18,21-heptaoxatricos-1-yl benzoate 
• 1454333-38-0 3,6,9,12,15,18,21,24,27,30-decaoxadotriacont-31-en-1-yl benzoate 
• 159896-90-9 C₂₂H₄₄O₁₁ 
• 1454333-42-6 5-iodo-3’-O-(1-methyl-33-oxo-33-phenyl-2,5,8,11,14,17,20,23,26,29,32-undecaoxadotritriacont-1-yl)-5’-O-triisopropylsilyl-2’-deoxyuridine 
• 133604-58-7 hexadecylethylene glycol monomethylether 
• 6812-36-8 hexadecaethylene glycol 
• 1351556-81-4 2-(2-{2-[2-(2-{2-[2-(2-prop-2-ynyloxyethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethoxy}ethoxy)ethanol 
• 1422541-07-8 C₄₆H₆₅N₃O₁₄S₂ 
• 1422541-06-7 C₄₇H₇₅N₉O₁₇ 
• 1333154-77-0 α-amino,ω-azido,α,ω-dideoxy-octaethyleneglycol 
• 1422541-00-1 C₂₃H₃₆N₄O₁₂ 
• 225523-86-4 α,ω-diazido,α,ω-dideoxy-octaethyleneglycol 
• 352439-36-2 α-(2-azidoethyl)-ω-hydroxyhexa(oxyethylene) 

Relevant articles and documents

PROTAC compound for targeted degradation of IDO1, and preparation method and application thereof

The invention provides a PROTAC compound represented by formula I and used for targeted degradation of IDO1, and a pharmaceutically acceptable salt, a hydrate or a solvate thereof. In the formula I, Xrepresents -CH2 or -C = O, Y represents -CH2 or -C= O, and n is a natural number from 2 to 9. The PROTAC compound for targeted degradation of the IDO1 has efficient activity of targeted degradation of the IDO1 protein.

Highly efficient synthesis of monodisperse poly(ethylene glycols) and derivatives through macrocyclization of oligo(ethylene glycols)

A macrocyclic sulfate (MCS)-based approach to monodisperse poly(ethylene glycols) (M-PEGs) and their monofunctionalized derivatives has been developed. Macrocyclization of oligo(ethylene glycols) (OEGs) provides MCS (up to a 62-membered macrocycle) as versatile precursors for a range of monofunctionalized M-PEGs. Through iterative nucleophilic ring-opening reactions of MCS without performing group protection and activation, a series of M-PEGs, including the unprecedented 64-mer (2850Da), can be readily prepared. Synthetic simplicity coupled with versatility of this new strategy may pave the way for broader applications of M-PEGs. Macrocycles make synthesis easier: Convenient macrocyclization of the OEGs provides versatile macrocyclic sulfates. These compounds are cornerstones for both monofunctionalization of OEGs and highly efficient synthesis of monodisperse PEGs and derivatives, including an unprecedented 64-mer.