methyl (R)-(-)-2-methyl-2-<(methylsulfonyl)oxy>-4-(2,4,5-trimethyl-3,6-dioxo-1,4-cyclohexadien-1-yl)butanoate

Base Information

Chemical Name:methyl (R)-(-)-2-methyl-2-<(methylsulfonyl)oxy>-4-(2,4,5-trimethyl-3,6-dioxo-1,4-cyclohexadien-1-yl)butanoate
CAS No.:70874-21-4
Molecular Formula:C₁₆H₂₂O₇S
Molecular Weight:358.412
Hs Code.:

Synonyms:methyl (R)-(-)-2-methyl-2-<(methylsulfonyl)oxy>-4-(2,4,5-trimethyl-3,6-dioxo-1,4-cyclohexadien-1-yl)butanoate

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Chemical Property of methyl (R)-(-)-2-methyl-2-<(methylsulfonyl)oxy>-4-(2,4,5-trimethyl-3,6-dioxo-1,4-cyclohexadien-1-yl)butanoate

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Technology Process of methyl (R)-(-)-2-methyl-2-<(methylsulfonyl)oxy>-4-(2,4,5-trimethyl-3,6-dioxo-1,4-cyclohexadien-1-yl)butanoate

There total 7 articles about methyl (R)-(-)-2-methyl-2-<(methylsulfonyl)oxy>-4-(2,4,5-trimethyl-3,6-dioxo-1,4-cyclohexadien-1-yl)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.5%

: 70874-20-3
methyl (R)-(-)-2-hydroxy-2-methyl-4-(3,4,5-trimethyl-3,6-dioxo-1,4-cyclohexadien-1-yl)butanoate

: 124-63-0
methanesulfonyl chloride

: 70874-21-4
methyl (R)-(-)-2-methyl-2-<(methylsulfonyl)oxy>-4-(2,4,5-trimethyl-3,6-dioxo-1,4-cyclohexadien-1-yl)butanoate

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 64h;
DOI:10.1021/jo00325a004

Reference yield:

: 70874-20-3
(R)-(-)-methyl 2-hydroxy-2-methyl-4-(2,4,5-trimethyl-3,6-dioxo-1,4-cyclohexadien-1-yl)-butanoate

: 124-63-0
methanesulfonyl chloride

: 70874-21-4
(R)-(-)-methyl 2-methyl-2-[(methylsulfonyl)oxy]-4-(2,4,5-trimethyl-3,6-dioxo-1,4-cyclohexadien-1-yl)butanoate

Guidance literature:: With triethylamine; In dichloromethane; water;

Reference yield:

: 77257-11-5
(R)-2-Hydroxy-2-methyl-4-(2,4,5-trimethyl-3,6-dioxo-cyclohexa-1,4-dienyl)-butyric acid

: 70874-21-4
methyl (R)-(-)-2-methyl-2-<(methylsulfonyl)oxy>-4-(2,4,5-trimethyl-3,6-dioxo-1,4-cyclohexadien-1-yl)butanoate

Guidance literature:: Multi-step reaction with 5 steps

1: 100 percent / H₂ / 5percent Pd/C / ethyl acetate

2: concd. HCl / 2 h / 90 °C

3: 94.7 percent / p-toluenesulfonic acid monohydrate / 3.75 h / Heating

4: 85 percent / ferric chloride / diethyl ether; methanol; H₂O / 0.5 h

5: 72.5 percent / Et₃N / CH₂Cl₂ / 64 h / 0 °C

With hydrogenchloride; hydrogen; iron(III) chloride; toluene-4-sulfonic acid; triethylamine; palladium on activated charcoal; In methanol; diethyl ether; dichloromethane; water; ethyl acetate;
DOI:10.1021/jo00325a004