Acetic acid (R)-2-[(1R,2S)-2-(tert-butyl-diphenyl-silanyloxymethyl)-1-methyl-5-oxo-cyclopentyl]-1-ethylsulfanylcarbonyl-ethyl ester

Base Information

Chemical Name:Acetic acid (R)-2-[(1R,2S)-2-(tert-butyl-diphenyl-silanyloxymethyl)-1-methyl-5-oxo-cyclopentyl]-1-ethylsulfanylcarbonyl-ethyl ester
CAS No.:493021-06-0
Molecular Formula:C₃₀H₄₀O₅SSi
Molecular Weight:540.796
Hs Code.:

Synonyms:Acetic acid (R)-2-[(1R,2S)-2-(tert-butyl-diphenyl-silanyloxymethyl)-1-methyl-5-oxo-cyclopentyl]-1-ethylsulfanylcarbonyl-ethyl ester

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Chemical Property of Acetic acid (R)-2-[(1R,2S)-2-(tert-butyl-diphenyl-silanyloxymethyl)-1-methyl-5-oxo-cyclopentyl]-1-ethylsulfanylcarbonyl-ethyl ester

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Technology Process of Acetic acid (R)-2-[(1R,2S)-2-(tert-butyl-diphenyl-silanyloxymethyl)-1-methyl-5-oxo-cyclopentyl]-1-ethylsulfanylcarbonyl-ethyl ester

There total 11 articles about Acetic acid (R)-2-[(1R,2S)-2-(tert-butyl-diphenyl-silanyloxymethyl)-1-methyl-5-oxo-cyclopentyl]-1-ethylsulfanylcarbonyl-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 75-08-1
ethanethiol

: 493021-10-6
(R)-2-Acetoxy-3-[(1R,2S)-2-(tert-butyl-diphenyl-silanyloxymethyl)-1-methyl-5-oxo-cyclopentyl]-propionic acid

: 493021-06-0
Acetic acid (R)-2-[(1R,2S)-2-(tert-butyl-diphenyl-silanyloxymethyl)-1-methyl-5-oxo-cyclopentyl]-1-ethylsulfanylcarbonyl-ethyl ester

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 0 - 20 ℃;
DOI:10.1021/ol027125o

Reference yield:

: 17553-86-5
(S)-Halos-Parish ketone

: 493021-06-0
Acetic acid (R)-2-[(1R,2S)-2-(tert-butyl-diphenyl-silanyloxymethyl)-1-methyl-5-oxo-cyclopentyl]-1-ethylsulfanylcarbonyl-ethyl ester

Guidance literature:: Multi-step reaction with 11 steps

1: 94 percent / sodium borohydride / ethanol / 4 h / -15 °C

2: 93 percent / pyridine; 4-(dimethylamino)pyridine / 0 - 20 °C

3: 85 percent / dimethylsulfoxide / 3 h / 20 °C

4: 95 percent / pTSA / benzene / 5 h / Heating

5: 91 percent / diisobutylaluminum hydride / toluene / 1 h / 0 °C

6: 96 percent / sodium borohydride / ethanol / 1.5 h / -20 °C

7: 95 percent / HCl / acetone / 2 h / 20 °C

8: 99 percent / imidazole / dimethylformamide / 0 - 20 °C

9: toluene / 31 h / 138 °C

10: 80 percent / sodium periodate; RuCl₃ / H₂O; CCl₄; acetonitrile / 7 h / 20 °C

11: 81 percent / N,N'-dicyclohexylcarbodiimide; 4-(dimethylamino)pyridine / CH₂Cl₂ / 0 - 20 °C

With pyridine; 1H-imidazole; hydrogenchloride; dmap; ruthenium trichloride; sodium tetrahydroborate; sodium periodate; diisobutylaluminium hydride; toluene-4-sulfonic acid; dicyclohexyl-carbodiimide; In tetrachloromethane; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone; toluene; acetonitrile; benzene;
DOI:10.1021/ol027125o

Reference yield:

: 16271-49-1
(1S,7aS)-1-hydroxy-7a-methyl-2,3,7,7a-tetrahydro-1H-inden-5(6H)-one

: 493021-06-0
Acetic acid (R)-2-[(1R,2S)-2-(tert-butyl-diphenyl-silanyloxymethyl)-1-methyl-5-oxo-cyclopentyl]-1-ethylsulfanylcarbonyl-ethyl ester

Guidance literature:: Multi-step reaction with 10 steps

1: 93 percent / pyridine; 4-(dimethylamino)pyridine / 0 - 20 °C

2: 85 percent / dimethylsulfoxide / 3 h / 20 °C

3: 95 percent / pTSA / benzene / 5 h / Heating

4: 91 percent / diisobutylaluminum hydride / toluene / 1 h / 0 °C

5: 96 percent / sodium borohydride / ethanol / 1.5 h / -20 °C

6: 95 percent / HCl / acetone / 2 h / 20 °C

7: 99 percent / imidazole / dimethylformamide / 0 - 20 °C

8: toluene / 31 h / 138 °C

9: 80 percent / sodium periodate; RuCl₃ / H₂O; CCl₄; acetonitrile / 7 h / 20 °C

10: 81 percent / N,N'-dicyclohexylcarbodiimide; 4-(dimethylamino)pyridine / CH₂Cl₂ / 0 - 20 °C

With pyridine; 1H-imidazole; hydrogenchloride; dmap; ruthenium trichloride; sodium tetrahydroborate; sodium periodate; diisobutylaluminium hydride; toluene-4-sulfonic acid; dicyclohexyl-carbodiimide; In tetrachloromethane; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone; toluene; acetonitrile; benzene;
DOI:10.1021/ol027125o