(2RS,3RS)-2-(3,4-Dimethoxyphenyl)-3-hydroxymethyl-1,4-benzodioxan-6-carbaldehyd

Base Information

• Chemical Name: (2RS,3RS)-2-(3,4-Dimethoxyphenyl)-3-hydroxymethyl-1,4-benzodioxan-6-carbaldehyd
• CAS No.: 100100-74-1
• Molecular Formula: C₁₈H₁₈O₆
• Molecular Weight: 330.337
• Mol file: 100100-74-1.mol

Synonyms:(2RS,3RS)-2-(3,4-Dimethoxyphenyl)-3-hydroxymethyl-1,4-benzodioxan-6-carbaldehyd

Chemical Property of (2RS,3RS)-2-(3,4-Dimethoxyphenyl)-3-hydroxymethyl-1,4-benzodioxan-6-carbaldehyd

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2RS,3RS)-2-(3,4-Dimethoxyphenyl)-3-hydroxymethyl-1,4-benzodioxan-6-carbaldehyd

There total 2 articles about (2RS,3RS)-2-(3,4-Dimethoxyphenyl)-3-hydroxymethyl-1,4-benzodioxan-6-carbaldehyd which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

rac-Americanin-A dimethylether (100100-73-0) → (2RS,3RS)-2-(3,4-Dimethoxyphenyl)-3-hydroxymethyl-1,4-benzodioxan-6-carbaldehyd (100100-74-1)

Guidance literature:

With sodium periodate; osmium(VIII) oxide; In 1,4-dioxane; for 12h; Ambient temperature;

Reference yield:

rac-Americanin-A (69506-79-2,76870-73-0,133906-60-2) → (2RS,3RS)-2-(3,4-Dimethoxyphenyl)-3-hydroxymethyl-1,4-benzodioxan-6-carbaldehyd (100100-74-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 35 percent / K₂CO₃ / acetone / Heating

2: 72 percent / OsO₄, NaIO₄ / dioxane / 12 h / Ambient temperature

With sodium periodate; osmium(VIII) oxide; potassium carbonate; In 1,4-dioxane; acetone;

Reference yield: 73.0%

(2RS,3RS)-2-(3,4-Dimethoxyphenyl)-3-hydroxymethyl-1,4-benzodioxan-6-carbaldehyd (100100-74-1) + methyl iodide (74-88-4) → (2RS,3RS)-2-(3,4-Dimethoxyphenyl)-3-methoxymethyl-1,4-benzodioxan-6-carbaldehyd (100100-75-2)

Guidance literature:

With silver(l) oxide; In acetone; at 55 ℃; for 72h;

upstream raw materials:

rac-Americanin-A dimethylether

rac-Americanin-A

Downstream raw materials:

(2RS,3RS)-3-Acetoxymethyl-2-(3,4-dimethoxyphenyl)-1,4-benzodioxan-6-carbaldehyd

(2RS,3RS)-2-(3,4-Dimethoxyphenyl)-3,6-bis(hydroxymethyl)-1,4-benzodioxan

(2RS,3RS)-2-(3,4-Dimethoxyphenyl)-3-methoxymethyl-1,4-benzodioxan-6-carbaldehyd

(2RS,3RS)-2-(3,4-Dimethoxyphenyl)-3-methoxymethyl-1,4-benzodioxan-6-carbonsaeure

Refernces