N⁵-benzyloxy-N¹-(4-hydroxybutyl)-N²-(4-methylbenzoyl)-L-glutamamide

Base Information

Chemical Name:N⁵-benzyloxy-N¹-(4-hydroxybutyl)-N²-(4-methylbenzoyl)-L-glutamamide
CAS No.:861819-87-6
Molecular Formula:C₂₄H₃₁N₃O₅
Molecular Weight:441.527
Hs Code.:

N<sup>5</sup>-benzyloxy-N<sup>1</sup>-(4-hydroxybutyl)-N<sup>2</sup>-(4-methylbenzoyl)-L-glutamamide

Synonyms:N⁵-benzyloxy-N¹-(4-hydroxybutyl)-N²-(4-methylbenzoyl)-L-glutamamide

Suppliers and Price of N⁵-benzyloxy-N¹-(4-hydroxybutyl)-N²-(4-methylbenzoyl)-L-glutamamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N⁵-benzyloxy-N¹-(4-hydroxybutyl)-N²-(4-methylbenzoyl)-L-glutamamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N⁵-benzyloxy-N¹-(4-hydroxybutyl)-N²-(4-methylbenzoyl)-L-glutamamide

There total 8 articles about N⁵-benzyloxy-N¹-(4-hydroxybutyl)-N²-(4-methylbenzoyl)-L-glutamamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 861819-86-5
N⁵-benzyloxy-N⁵-[(benzyloxy)carbonyl]-N²-(4-methylbenzoyl)-L-glutamine

: 13325-10-5
4-Aminobutanol

: 861819-87-6
N⁵-benzyloxy-N¹-(4-hydroxybutyl)-N²-(4-methylbenzoyl)-L-glutamamide

Guidance literature:: With 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 16h;
DOI:10.1016/j.bmc.2005.04.051

Reference yield:

: 223467-27-4
5-benzyl 1-tert-butyl N-(4-methylbenzoyl)-L-glutamate

: 861819-87-6
N⁵-benzyloxy-N¹-(4-hydroxybutyl)-N²-(4-methylbenzoyl)-L-glutamamide

Guidance literature:: Multi-step reaction with 4 steps

1: 76 percent / H₂ / Pd-C / ethanol / 20 °C / atmospheric pressure

2: 88 percent / 4-(dimethylamino)pyridine; 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide*HCl / dimethylformamide / 16 h / 20 °C

3: 56 percent / CF₃CO₂H / 3 h / 20 °C

4: 57 percent / 1-hydroxybenzotriazole monohydrate; triethylamine; 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide*HCl / dimethylformamide / 16 h / 20 °C

With dmap; hydrogen; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2005.04.051

Reference yield:

: 874-60-2
4-methyl-benzoyl chloride

: 861819-87-6
N⁵-benzyloxy-N¹-(4-hydroxybutyl)-N²-(4-methylbenzoyl)-L-glutamamide

Guidance literature:: Multi-step reaction with 5 steps

1: 100 percent / N,N-diisopropylethylamine / CHCl₃ / 1 h / 20 °C

2: 76 percent / H₂ / Pd-C / ethanol / 20 °C / atmospheric pressure

3: 88 percent / 4-(dimethylamino)pyridine; 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide*HCl / dimethylformamide / 16 h / 20 °C

4: 56 percent / CF₃CO₂H / 3 h / 20 °C

5: 57 percent / 1-hydroxybenzotriazole monohydrate; triethylamine; 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide*HCl / dimethylformamide / 16 h / 20 °C

With dmap; hydrogen; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium on activated charcoal; In ethanol; chloroform; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2005.04.051