C₂₄H₂₁F₄N₃O₄

Base Information

• Chemical Name: C₂₄H₂₁F₄N₃O₄
• CAS No.: 1590403-75-0
• Molecular Formula: C₂₄H₂₁F₄N₃O₄
• Molecular Weight: 491.442
• Mol file: 1590403-75-0.mol

Synonyms:C₂₄H₂₁F₄N₃O₄

Chemical Property of C₂₄H₂₁F₄N₃O₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₄H₂₁F₄N₃O₄

There total 11 articles about C₂₄H₂₁F₄N₃O₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

C32H27F4N3O6 (1590411-01-0) → C24H21F4N3O4 (1590403-75-0)

Guidance literature:

With palladium on activated charcoal; hydrogen; In ethanol; at 20 ℃; for 4h;

Reference yield:

2,4-dimethoxypyridine (18677-43-5) → C24H21F4N3O4 (1590403-75-0)

Guidance literature:

Multi-step reaction with 8 steps

1.1: N-Bromosuccinimide / acetonitrile / 12 h / 70 - 85 °C / Darkness

2.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,2-dimethoxyethane / 10 h / 90 - 100 °C / Inert atmosphere

3.1: hydrogen bromide / water / 7 h / 100 °C

4.1: copper diacetate; pyridine N-oxide; pyridine; oxygen / dichloromethane / 38 h / 20 °C / Molecular sieve

5.1: boron tribromide / dichloromethane / 36 h / -70 - 30 °C

6.1: N,N-dimethyl-aniline; trichlorophosphate / dichloromethane / 2 h / 100 °C

7.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C

7.2: 20 °C

8.1: hydrogen; palladium on activated charcoal / ethanol / 4 h / 20 °C

With pyridine; pyridine N-oxide; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium on activated charcoal; hydrogen bromide; hydrogen; oxygen; copper diacetate; boron tribromide; sodium hydride; potassium carbonate; N,N-dimethyl-aniline; trichlorophosphate; In 1,2-dimethoxyethane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; mineral oil;

Reference yield:

2,4-dichloropyridine (26452-80-2) → C24H21F4N3O4 (1590403-75-0)

Guidance literature:

Multi-step reaction with 9 steps

1.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 12 h / 110 - 120 °C / Inert atmosphere

2.1: N-Bromosuccinimide / acetonitrile / 12 h / 70 - 85 °C / Darkness

3.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,2-dimethoxyethane / 10 h / 90 - 100 °C / Inert atmosphere

4.1: hydrogen bromide / water / 7 h / 100 °C

5.1: copper diacetate; pyridine N-oxide; pyridine; oxygen / dichloromethane / 38 h / 20 °C / Molecular sieve

6.1: boron tribromide / dichloromethane / 36 h / -70 - 30 °C

7.1: N,N-dimethyl-aniline; trichlorophosphate / dichloromethane / 2 h / 100 °C

8.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C

8.2: 20 °C

9.1: hydrogen; palladium on activated charcoal / ethanol / 4 h / 20 °C

With pyridine; pyridine N-oxide; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium on activated charcoal; hydrogen bromide; hydrogen; oxygen; copper diacetate; boron tribromide; sodium hydride; potassium carbonate; N,N-dimethyl-aniline; trichlorophosphate; In 1,2-dimethoxyethane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; mineral oil;

upstream raw materials:

2,4-dichloropyridine

2,4-dimethoxypyridine

5-bromo-2,4-dimethoxypyridine

C₁₃H₁₂FNO₂