2-Acetamido-5-chlorothiazole

Base Information

• Chemical Name: 2-Acetamido-5-chlorothiazole
• CAS No.: 20256-39-7
• Molecular Formula: C5H5 Cl N2 O S
• Molecular Weight: 176.62
• Hs Code.: 2934100090
• European Community (EC) Number: 626-334-2
• DSSTox Substance ID: DTXSID60405537
• Wikidata: Q82210136
• Mol file: 20256-39-7.mol

Synonyms:2-Acetamido-5-chlorothiazole;20256-39-7;N-(5-chlorothiazol-2-yl)acetamide;N-(5-chloro-1,3-thiazol-2-yl)acetamide;Acetamide, N-(5-chloro-2-thiazolyl)-;2-acetylamino-5-chlorothiazole;2-Acetamido-5-chlorothiazolev;SCHEMBL966406;DTXSID60405537;YLRXYIGXXMJPOP-UHFFFAOYSA-N;2-Acetamido-5-chlorothiazole, 96%;MFCD01318098;AKOS024258475;AS-62940;N-(5-chloro-1, 3-thiazol-2-yl)acetamide;CS-0128348;FT-0610925;D97755;A814362;J-013153

Chemical Property of 2-Acetamido-5-chlorothiazole

Chemical Property:

• Melting Point: 208-210°C
• Refractive Index: 1.633
• Boiling Point: °Cat760mmHg
• PKA: 9.03±0.50(Predicted)
• Flash Point: °C
• PSA: 70.23000
• Density: 1.507g/cm³
• LogP: 1.82790
• Storage Temp.: Inert atmosphere,Room Temperature
• XLogP3: 2.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 175.9811117
• Heavy Atom Count: 10
• Complexity: 144

Purity/Quality:

97% ^*data from raw suppliers

2-Acetamido-5-chlorothiazole 96% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 36/37/38-22
• Safety Statements: 26-36-36/37

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)NC1=NC=C(S1)Cl

Technology Process of 2-Acetamido-5-chlorothiazole

There total 1 articles about 2-Acetamido-5-chlorothiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

2-acetamidothiazole (2719-23-5) → N-(5-chlorothiazol-2-yl)acetamide (20256-39-7)

Guidance literature:

With hydrogenchloride; (4s,6s)-2,4,5,6-tetra(9H-carbazol-9-yl)isophthalonitrile; hydrogen bromide; oxygen; In water; acetonitrile; at 25 ℃; for 1.5h; regioselective reaction; Irradiation;

DOI:10.1002/ejoc.201900411

Reference yield:

N-(5-chlorothiazol-2-yl)acetamide (20256-39-7) + 4-Methoxybenzenethiol (696-63-9) → 2-acetylamino-5-(4-methoxyphenylthio)thiazole (133691-85-7)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide;

Reference yield:

N-(5-chlorothiazol-2-yl)acetamide (20256-39-7) + 4-sulfanylphenol (637-89-8) → 2-acetylamino-5-(4-hydroxyphenylthio)thiazole (133691-83-5)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide;

upstream raw materials:

2-acetamidothiazole

Downstream raw materials:

2-amino-5-chlorothiazole

2-acetylamino-5-(4-aminophenylthio)thiazole

2-acetylamino-5-(4-methoxyphenylthio)thiazole

2-acetylamino-5-(4-hydroxyphenylthio)thiazole