Technology Process of 4-(5-chloro-6-cyclopropylpyridin-3-yloxy)-3-(2-methoxypyridin-3-yl)-N-(methylsulfonyl)benzamide
There total 6 articles about 4-(5-chloro-6-cyclopropylpyridin-3-yloxy)-3-(2-methoxypyridin-3-yl)-N-(methylsulfonyl)benzamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
4-(5-chloro-6-cyclopropylpyridin-3-yloxy)-3-(2-methoxypyridin-3-yl)benzamide;
With
lithium hexamethyldisilazane;
In
tetrahydrofuran;
at 20 ℃;
for 0.5h;
Inert atmosphere;
methanesulfonyl chloride;
In
tetrahydrofuran;
at 20 ℃;
for 2h;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: potassium phosphate / palladium diacetate; tricyclohexylphosphine / water; toluene / 22 h / 20 - 100 °C / Inert atmosphere
2.1: bis(pinacol)diborane / (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; 4,4'-di-tert-butyl-2,2'-bipyridine / n-heptane / 18 h / 20 °C / Inert atmosphere
2.2: 1 h
3.1: potassium carbonate / dimethyl sulfoxide / 5 h / 50 °C
4.1: caesium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 75 °C / Inert atmosphere
5.1: dihydrogen peroxide; potassium carbonate / water; dimethyl sulfoxide / 1 h / 20 °C
6.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere
6.2: 2 h / 20 °C
With
potassium phosphate; dihydrogen peroxide; potassium carbonate; caesium carbonate; bis(pinacol)diborane; lithium hexamethyldisilazane;
tetrakis(triphenylphosphine) palladium(0); (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; palladium diacetate; 4,4'-di-tert-butyl-2,2'-bipyridine; tricyclohexylphosphine;
In
tetrahydrofuran; 1,4-dioxane; n-heptane; water; dimethyl sulfoxide; toluene;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: bis(pinacol)diborane / (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; 4,4'-di-tert-butyl-2,2'-bipyridine / n-heptane / 18 h / 20 °C / Inert atmosphere
1.2: 1 h
2.1: potassium carbonate / dimethyl sulfoxide / 5 h / 50 °C
3.1: caesium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 75 °C / Inert atmosphere
4.1: dihydrogen peroxide; potassium carbonate / water; dimethyl sulfoxide / 1 h / 20 °C
5.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere
5.2: 2 h / 20 °C
With
dihydrogen peroxide; potassium carbonate; caesium carbonate; bis(pinacol)diborane; lithium hexamethyldisilazane;
tetrakis(triphenylphosphine) palladium(0); (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; 4,4'-di-tert-butyl-2,2'-bipyridine;
In
tetrahydrofuran; 1,4-dioxane; n-heptane; water; dimethyl sulfoxide;
