cis-4-{[6-(biphenyl-4-ylcarbonyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl]amino}cyclohexanecarboxylic acid

Base Information

Chemical Name:cis-4-{[6-(biphenyl-4-ylcarbonyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl]amino}cyclohexanecarboxylic acid
CAS No.:1332455-33-0
Molecular Formula:C₂₇H₂₈N₄O₃
Molecular Weight:456.544
Hs Code.:

Synonyms:cis-4-{[6-(biphenyl-4-ylcarbonyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl]amino}cyclohexanecarboxylic acid

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Chemical Property of cis-4-{[6-(biphenyl-4-ylcarbonyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl]amino}cyclohexanecarboxylic acid

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Technology Process of cis-4-{[6-(biphenyl-4-ylcarbonyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl]amino}cyclohexanecarboxylic acid

There total 5 articles about cis-4-{[6-(biphenyl-4-ylcarbonyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl]amino}cyclohexanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1332455-32-9
biphenyl-4-yl-(4-chloro-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)methanone

: 3685-23-2
cis-4-aminocyclohexane-1-carboxylic acid

: 1332455-33-0
cis-4-{[6-(biphenyl-4-ylcarbonyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl]amino}cyclohexanecarboxylic acid

Guidance literature:: With potassium carbonate; In dimethyl sulfoxide; at 80 ℃; for 4h;

Reference yield:

: 109229-22-3
6-benzyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one

: 1332455-33-0
cis-4-{[6-(biphenyl-4-ylcarbonyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl]amino}cyclohexanecarboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine; formic acid / palladium(II) hydroxide / methanol / 5.5 h / 60 °C

2: sodium hydrogencarbonate / water; tetrahydrofuran / 3.25 h / 0 - 25 °C

3: trichlorophosphate / N,N-dimethyl-formamide / acetonitrile / 5 h / 70 °C

4: potassium carbonate / dimethyl sulfoxide / 4 h / 80 °C

With formic acid; sodium hydrogencarbonate; potassium carbonate; triethylamine; trichlorophosphate; palladium(II) hydroxide; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; water; dimethyl sulfoxide; acetonitrile;

Reference yield:

: 756437-41-9
5,6,7,8-tetrahydro-3H-pyrido[4,3-d]pyrimidin-4-one

: 1332455-33-0
cis-4-{[6-(biphenyl-4-ylcarbonyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl]amino}cyclohexanecarboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydrogencarbonate / water; tetrahydrofuran / 3.25 h / 0 - 25 °C

2: trichlorophosphate / N,N-dimethyl-formamide / acetonitrile / 5 h / 70 °C

3: potassium carbonate / dimethyl sulfoxide / 4 h / 80 °C

With sodium hydrogencarbonate; potassium carbonate; trichlorophosphate; N,N-dimethyl-formamide; In tetrahydrofuran; water; dimethyl sulfoxide; acetonitrile;