ethyl cis-4-{[6-(biphenyl-4-ylcarbonyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl]amino}cyclohexanecarboxylate

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Chemical Name:ethyl cis-4-{[6-(biphenyl-4-ylcarbonyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl]amino}cyclohexanecarboxylate
CAS No.:1332455-22-7
Molecular Formula:C₂₉H₃₂N₄O₃
Molecular Weight:484.598
Hs Code.:

Synonyms:ethyl cis-4-{[6-(biphenyl-4-ylcarbonyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl]amino}cyclohexanecarboxylate

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Chemical Property of ethyl cis-4-{[6-(biphenyl-4-ylcarbonyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl]amino}cyclohexanecarboxylate

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Technology Process of ethyl cis-4-{[6-(biphenyl-4-ylcarbonyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl]amino}cyclohexanecarboxylate

There total 6 articles about ethyl cis-4-{[6-(biphenyl-4-ylcarbonyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl]amino}cyclohexanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 64-17-5
ethanol

: 1332455-33-0
cis-4-{[6-(biphenyl-4-ylcarbonyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl]amino}cyclohexanecarboxylic acid

: 1332455-22-7
ethyl cis-4-{[6-(biphenyl-4-ylcarbonyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl]amino}cyclohexanecarboxylate

Guidance literature:: With thionyl chloride; at 0 - 25 ℃;

Reference yield:

: 109229-22-3
6-benzyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one

: 1332455-22-7
ethyl cis-4-{[6-(biphenyl-4-ylcarbonyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl]amino}cyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine; formic acid / palladium(II) hydroxide / methanol / 5.5 h / 60 °C

2: sodium hydrogencarbonate / water; tetrahydrofuran / 3.25 h / 0 - 25 °C

3: trichlorophosphate / N,N-dimethyl-formamide / acetonitrile / 5 h / 70 °C

4: potassium carbonate / dimethyl sulfoxide / 4 h / 80 °C

5: thionyl chloride / 0 - 25 °C

With formic acid; thionyl chloride; sodium hydrogencarbonate; potassium carbonate; triethylamine; trichlorophosphate; palladium(II) hydroxide; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; water; dimethyl sulfoxide; acetonitrile;

Reference yield:

: 756437-41-9
5,6,7,8-tetrahydro-3H-pyrido[4,3-d]pyrimidin-4-one

: 1332455-22-7
ethyl cis-4-{[6-(biphenyl-4-ylcarbonyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl]amino}cyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydrogencarbonate / water; tetrahydrofuran / 3.25 h / 0 - 25 °C

2: trichlorophosphate / N,N-dimethyl-formamide / acetonitrile / 5 h / 70 °C

3: potassium carbonate / dimethyl sulfoxide / 4 h / 80 °C

4: thionyl chloride / 0 - 25 °C

With thionyl chloride; sodium hydrogencarbonate; potassium carbonate; trichlorophosphate; N,N-dimethyl-formamide; In tetrahydrofuran; water; dimethyl sulfoxide; acetonitrile;