2-methyl-5-nitro-4-(phenylmethyl)thio-3-thiophenecarboxylic acid methyl ester

Base Information

Chemical Name:2-methyl-5-nitro-4-(phenylmethyl)thio-3-thiophenecarboxylic acid methyl ester
CAS No.:227312-13-2
Molecular Formula:C₁₄H₁₃NO₄S₂
Molecular Weight:323.394
Hs Code.:

Synonyms:2-methyl-5-nitro-4-(phenylmethyl)thio-3-thiophenecarboxylic acid methyl ester

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Chemical Property of 2-methyl-5-nitro-4-(phenylmethyl)thio-3-thiophenecarboxylic acid methyl ester

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Technology Process of 2-methyl-5-nitro-4-(phenylmethyl)thio-3-thiophenecarboxylic acid methyl ester

There total 4 articles about 2-methyl-5-nitro-4-(phenylmethyl)thio-3-thiophenecarboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 100-53-8
phenylmethanethiol

: 227312-10-9
2-methyl-4-((4-methylphenyl)sulfonyl)oxy-5-nitro-3-thiophenecarboxylic acid methyl ester

: 227312-13-2
2-methyl-5-nitro-4-(phenylmethyl)thio-3-thiophenecarboxylic acid methyl ester

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide;
DOI:10.1007/PL00010236

Reference yield:

: 65369-27-9
2-Methyl-4-oxo-tetrahydrothiophen-3-carbonsaeuremethylester

: 227312-13-2
2-methyl-5-nitro-4-(phenylmethyl)thio-3-thiophenecarboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: NaH / dimethylformamide / Ambient temperature

2: 71 percent / SO₂Cl₂ / CH₂Cl₂ / Ambient temperature

3: 66 percent / fum. HNO₃, conc. H₂SO₄ / acetic anhydride / Ambient temperature

4: 85 percent / K₂CO₃ / dimethylformamide

With sulfuryl dichloride; sulfuric acid; nitric acid; sodium hydride; potassium carbonate; In dichloromethane; acetic anhydride; N,N-dimethyl-formamide;
DOI:10.1007/PL00010236

Reference yield:

: 227312-08-5
2-methyl-4-((4-methylphenyl)sulfonyl)oxy-3-thiophenecarboxylic acid methyl ester

: 227312-13-2
2-methyl-5-nitro-4-(phenylmethyl)thio-3-thiophenecarboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 66 percent / fum. HNO₃, conc. H₂SO₄ / acetic anhydride / Ambient temperature

2: 85 percent / K₂CO₃ / dimethylformamide

With sulfuric acid; nitric acid; potassium carbonate; In acetic anhydride; N,N-dimethyl-formamide;
DOI:10.1007/PL00010236