4-(((4-fluorophenyl)sulfonamido)methyl)cyclohexane-1-carboxylic acid

Base Information

• Chemical Name: 4-(((4-fluorophenyl)sulfonamido)methyl)cyclohexane-1-carboxylic acid
• CAS No.: 744248-54-2
• Molecular Formula: C₁₄H₁₈FNO₄S
• Molecular Weight: 315.366
• Mol file: 744248-54-2.mol

Synonyms:4-(((4-fluorophenyl)sulfonamido)methyl)cyclohexane-1-carboxylic acid

Chemical Property of 4-(((4-fluorophenyl)sulfonamido)methyl)cyclohexane-1-carboxylic acid

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(((4-fluorophenyl)sulfonamido)methyl)cyclohexane-1-carboxylic acid

There total 1 articles about 4-(((4-fluorophenyl)sulfonamido)methyl)cyclohexane-1-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

4-Fluorobenzenesulfonyl chloride (349-88-2) + trans-4-aminomethyl-cyclohexyl-carboxylic acid (1197-18-8) → 4-(((4-fluorophenyl)sulfonamido)methyl)cyclohexane-1-carboxylic acid (744248-54-2)

Guidance literature:

With sodium hydroxide; In dichloromethane; at 0 - 20 ℃; for 24h;

DOI:10.1016/j.bmcl.2019.126778

Reference yield: 97.0%

pyridin-3-ylamine (462-08-8) + 4-(((4-fluorophenyl)sulfonamido)methyl)cyclohexane-1-carboxylic acid (744248-54-2) → 4-(((4-fluorophenyl)sulfonamido)methyl)-N-(pyridin-3-yl)cyclohexane-1-carboxamide

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl acetamide; at 20 ℃; for 24h;

DOI:10.1016/j.bmcl.2019.126778

Reference yield: 27.0%

3,4-dichlorophenylhydrazine hydrochloride (19763-90-7) + 4-(((4-fluorophenyl)sulfonamido)methyl)cyclohexane-1-carboxylic acid (744248-54-2) → N-{4-[N'-(3,4-dichloro-phenyl)-hydrazinocarbonyl]-cyclohexylmethyl}-4-fluoro-benzenesulfonamide

Guidance literature:

4-(((4-fluorophenyl)sulfonamido)methyl)cyclohexane-1-carboxylic acid; With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 ℃; for 1h;

3,4-dichlorophenylhydrazine hydrochloride; With triethylamine; In dichloromethane; at 20 ℃; for 24h;

DOI:10.1016/j.bmc.2004.06.023

upstream raw materials:

4-Fluorobenzenesulfonyl chloride

trans-4-aminomethyl-cyclohexyl-carboxylic acid